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dc.contributor.authorHussain, Akhtar-
dc.contributor.authorSaha, Sounik-
dc.contributor.authorMajumdar, Ritankar-
dc.contributor.authorDighe, Rajan R-
dc.contributor.authorChakravarty, Akhil R-
dc.identifier.issn0975-0975(Online); 0376-4710(Print)-
dc.description.abstractLanthanide(III) complexes [La(B)(acac)3] (13) and [Gd(B)(acac)3]  (46), where B is a N,N-donor phenanthroline base, viz., 1,10-phenanthroline (phen in 1, 4), dipyrido[3,2-d:2ʹ,3ʹ-f]quinoxaline (dpq in 2, 5) and dipyrido[3,2-a:2ʹ,3ʹ-c]phena­zine (dppz in 3, 6), have been prepared and characterized. The Gd(III) complexes 46 are structurally characterized by single crystal X-ray crystallography. The complexes display GdO6N2 coordination with the ligands showing bidentate chelating mode of bonding. The complexes are non-electrolytic in aqueous DMF and exhibit ligand-centered absorption bands in the UV region. The dppz complexes show a band at 380 nm in DMF. The La(III) complexes are diamagnetic. The Gd(III) complexes are paramagnetic with magnetic moment that corresponds to seven unpaired electrons. The complexes are avid binders to calf thymus DNA giving Kb values in the range of 4.7 x 104 - 6.1 x 105 M-1 with a relative binding order: 3, 6 (dppz) > 2, 5 (dpq) > 1, 4 (phen). The binding data suggest DNA surface and/or groove binding nature of the complexes. The dpq and dppz complexes efficiently cleave SC DNA to its nicked circular form in UV-A light of 365 nm via formation of both singlet oxygen (1O2) and hydroxyl radical (HO) species. The dppz complexes 3 and 6 exhibit significant PDT effect in HeLa cervical cancer cells giving respective IC50 value of 460(±50) and 530(±30) nM in UV-A light of 365 nm, and are essentially non-toxic in dark with an IC50 value of >100 M. The dppz ligand alone is cytotoxic in dark and UV-A light. A significant decrease in the dark toxicity of the dppz base is observed on binding to the Ln(III) ion while retaining its photocytotoxicity.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-A Vol.50A(03-04) [March-April 2011]en_US
dc.subjectBioinorganic chemistryen_US
dc.subjectPhenanthroline basesen_US
dc.subjectCrystal structuresen_US
dc.subjectDNA bindingen_US
dc.subjectDNA photocleavageen_US
dc.titlePhotocytotoxicity and DNA photocleavage activity of La(III) and Gd(III) complexes of phenanthroline basesen_US
Appears in Collections:IJC-A Vol.50A(03-04) [March-April 2011]

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