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Title: Conventional as well as microwave assisted synthesis and antimicrobial screening of 4-aryl-3-chloro-1-[(5-nitroindazol-1-yl) acetamido]-2-oxo-azetidines
Authors: Upadhyay, Apoorva
Srivastava, S K
Srivastava, S D
Yadav, R
Keywords: 5-Nitroindazole;azetidinones;conventional and microwave synthesis;antimicrobial agents
Issue Date: Jan-2011
Publisher: NISCAIR-CSIR, India
Abstract: Several new 4-aryl-3-chloro-1-[(5-nitroindazol-1-yl) acetamido]-2-oxo-azetidines 4a-l have been synthesized from 2-(5-nitroindazol-1-yl) acetamidyl amino arylidenes 3a-l. The reactions have been carried out by both conventional as well as microwave method. The structures of all these compounds are confirmed by IR, 1H and 13C NMR, FAB-mass spectra and also by microanalytical data. All the synthesized compounds have been screened for their antibacterial activity against Escherichia coli, Bacillus subtilis and Salmonella typhi and antifungal activity against Aspergillus flavus, Penicillium citrinum and Fusarium oxysporum. Some of the synthesized compounds exhibit significant antibacterial and antifungal activities.
Page(s): 89-97
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(01) [January 2011]

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