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Title: Quantitative structure activity relationships for the nematicidal activity of 4-amino-5-substituted aryl-3-mercapto-(4H)-1,2,4-triazoles
Authors: Bijul, Lakshman A
Gupta, R L
Prasad, D
Keywords: QSAR;1,2,4-triazoles;agrochemicals;nematicidal activity;Meloidogyne incognita;Rotylenchulus reniformis
Issue Date: Dec-2010
Publisher: NISCAIR-CSIR, India
Abstract: The relationship between the structure of a series 4-amino-5-substituted aryl-3-mercapto-(4H)-1,2,4-triazoles and their nematicidal activity against Meloidogyne incognita and Rotylenchulus reniformis has been analyzed using physicochemical parameters for hydrophobic, electronic and steric properties of the  molecules by means of multiple regression analysis. The activity of the compounds predicted based on the QSAR models has been found comparable with the experimental values. The QSAR study reveals that the nematicidal activity against both nematodes is dependent on the electronic effect of ortho substituent [F], bulkiness of  para substituent [MR (p)] and width of meta substituent  [B4 (m)] of benzene ring substituents. The higher values of these parameters are favourable for nematicidal activity.
Page(s): 1657-1661
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(12) December 2010]

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