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http://nopr.niscpr.res.in/handle/123456789/10404| Title: | Microwave-assisted synthesis and antibacterial activity of 1-[3-(3-fluorophenyl) [1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-1H-4-pyrazolecarbaldehydes using solid support |
| Authors: | Mogilaiah, K Shiva Prasad, R Shiva Kumar, K |
| Keywords: | Pyrazolecarbaldehydes;1,8-naphthyridine;2H-2-chromenones;Vilsmeier-Haack reagent;solid support;microwave irradiation |
| Issue Date: | Oct-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A simple and efficient method for the synthesis of 1-[3-(3-fluorophenyl)[1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-H-4-pyrazolecarbaldehydes 4 from 3-[2-(3-(3-fluorophenyl)[1,8]-naphthyridin-2-yl)ethanhydrazonyl]-2H-2-chromenones (hydrazones) 3 in the presence of DMF-POCl3 (Vilsmeier-Haack reagent) using silica gel as solid support under microwave irradiation is described. The structural assignments to compounds 3 and 4 are based on their elemental analyses and spectral data. Compounds 4 have been tested for their antibacterial activity. |
| Page(s): | 1417-1421 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.49B(10) [October 2010] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 49B(10) 1417-1421.pdf | 109.85 kB | Adobe PDF | View/Open |
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