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Title: Microwave-assisted synthesis and antibacterial activity of 1-[3-(3-fluorophenyl) [1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-1H-4-pyrazolecarbaldehydes using solid support
Authors: Mogilaiah, K
Shiva Prasad, R
Shiva Kumar, K
Keywords: Pyrazolecarbaldehydes;1,8-naphthyridine;2H-2-chromenones;Vilsmeier-Haack reagent;solid support;microwave irradiation
Issue Date: Oct-2010
Publisher: NISCAIR-CSIR, India
Abstract: A simple and efficient method for the synthesis of 1-[3-(3-fluorophenyl)[1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-H-4-pyrazolecarbaldehydes 4 from 3-[2-(3-(3-fluorophenyl)[1,8]-naphthyridin-2-yl)ethanhydrazonyl]-2H-2-chromenones (hydra¬≠zones) 3 in the presence of DMF-POCl3 (Vilsmeier-Haack reagent) using silica gel as solid support under microwave irradiation is described. The structural assignments to compounds 3 and 4 are based on their elemental analyses and spectral data. Compounds 4 have been tested for their antibacterial activity.
Page(s): 1417-1421
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(10) [October 2010]

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