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Title: Synthesis of some biologically important fluorinated 3-chlorochromones and 1,5-benzothiazepines as antimicrobial and antifungal agents
Authors: Ghotekar, D S
Joshi, R S
Mandhane, P G
Bhagat, S S
Gill, C H
Keywords: Chalcones;3-chlorochromones;1,5-benzo¬thia¬zepines;antimicrobial;antifungal agents
Issue Date: Sep-2010
Publisher: CSIR
Abstract: A series of synthetic 3-chlorochromones and 1,5-benzo­thiazepines have been synthesized and evaluated for their antimicrobial and antifungal activity against Gram +ve and Gram -ve microorganisms. In these series the chemical transformation of chalcones to respective 3-chlorochromones and 1,5-benzothia­zepines by using DMSO/CuCl2 and 2-aminothiophenol respective­ly has been carried out. Compounds synthesized have been screened for antibacterial activity using Gentamycin and Cefixime and for antifungal activity using Ketoconazole as reference drugs.
Page(s): 1267-1270
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(09) [September 2010]

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