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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(08) [August 2010] >
| Title: | Effect of combined treatment of thioperamide with some antiepileptic drugs on methionine-sulfoximine induced convulsions in mice |
| Authors: | Vohora, Divya
Khanam, Razia
Pal, Shanthi N
Pillai, K K |
| Keywords: | Gabapentin
Methionine-sulfoximine
Sodium valproate
Thioperamide |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | Methionine-sulfoximine
(MSO), a convulsant is known to
increase
the activity of histamine N-methyl transferase. The effect of a selective H3
receptor agonist R- ( ) methylhistamine (RAMH) and antagonist (thioperamide,
THP) and some
antiepileptic
drugs (gabapentin and sodium valproate) have been evaluated on MSO-induced
convulsions in mice. The effect of THP was also evaluated in combination with
these antiepileptic drugs. Sodium valproate (300 mg/kg, po) and gabapentin
(400
mg/kg, po) offered protection against MSO-induced convulsions as evidenced by a
significant prolongation of latency to abnormal dorsoflexion and complete
protection against mortality within 6 h of administration. THP (15 mg/kg, ip)
alone and in combination with sub-effective doses of gabapentin (75 mg/kg, po)
and sodium valproate (75 mg/kg, po) revealed no significant differences from
the control group or either drug alone. Hence,
the
convulsant action of MSO does not appear to be mediated
via
histaminergic mechanisms. |
| Page(s): | 858-860 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(08) [August 2010]
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