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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(08) [August 2010] >
| Title: | Effect of Aloe vera gel extract on antioxidant enzymes and azoxymethane-induced oxidative stress in rats |
| Authors: | Anilakumar, K R
Sudarshanakrishna, K R
Chandramohan, G
Ilaiyaraja, N
Khanum, Farhath
Bawa, A S |
| Keywords: | Aloe vera gel extract
Azoxymethane
Detoxifying enzymes
Micronuclei
Rat liver |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | The
present work was undertaken with a view to study the
effect of oral feeding of 2% Aloe vera gel extract (AGE) for 30 days on
azoxymethane (AOM)-induced oxidative stress in rats. It was observed that AOM
administration resulted in a significant increase in malondialdehyde and
conjugated dienes, with reduction in hepatic glutathione (GSH), vitamin A and
uric acid contents. AOM-induced reduction in hepatic GSH and uric acid was
brought back to normal by AGE. There was a significant raise in hepatic catalase,
superoxide dismutase and glucose-6-phosphate dehydrogenase (G-6-PD) activities as
a result of feeding of the extract. Ingestion of the extract effected reduction
in AOM-induced colonic GSH-peroxidase, G-6- PD and glutathione S-transferase
and femur bone marrow micronuclei formation. Hence, it is suggested that Aloe
vera gel extract possess the ability to reduce AOM- induced oxidative
stress and toxicity in liver. |
| Page(s): | 837-842 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(08) [August 2010]
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