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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(08) [August 2010] >
| Title: | Effect of maternal fluoride exposure on developing CNS of rats: Protective role of Aloe vera, Curcuma longa and Ocimum sanctum |
| Authors: | Madhusudhan, N
Basha, P Mahaboob
Rai, Puja
Ahmed, Fiyaz
Prasad, G Ravi |
| Keywords: | Fluoride toxicity
Lipid peroxidation
Oxidative stress
Phytoextracts |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | Fluoride is toxic to neuronal development
and its excessive intake during pregnancy cause adverse effects on neonatal
development. The present study examined the presence of oxidative stress during
maternal exposure of fluoride and the therapeutic strategy of Aloe vera, Curcuma longa and Ocimum sanctum extracts in functional
prevention of fluoride led oxidative stress. The pregnant Wistar rats were
exposed to 100 ppm fluoride in drinking water and pups born to them were supplemented
with phytoextracts daily. On 21st postpartum day, the pups were sacrificed
to analyse fluoride and oxidative stress markers. Fluoride exposure
significantly increased its accumulation, lipid peroxidation and decreased the activities
of catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase
and glutathione levels in discrete regions of the central nervous system (CNS)
of pups indicating oxidative stress and inhibited antioxidant defense. The results
implied the vulnerability of developing CNS to fluoride toxicity. On
phytoextract supplementation, the oxidant devastation was suppressed by
regaining antioxidant homeostasis near normal level proving efficacy and
therapeutic strategy. Among the phytoextracts supplemented the Ocimum sanctum is found to be more
effective. |
| Page(s): | 830-836 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(08) [August 2010]
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