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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(08) [August 2010] >
| Title: | Hepatoprotective activity of Luffa acutangula against CCl4 and rifampicin induced liver toxicity in rats: A biochemical and histopathological evaluation |
| Authors: | Jadhav, Vishal B
Thakare, Vishnu N
Suralkar, Anupama A
Deshpande, Avinash D
Naik, Suresh R |
| Keywords: | Antioxidant
Hepatoprotection
Luffa acutangula
Serum marker enzymes |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | Hepatoprotective activity of hydroalcoholic
extract of Luffa acutangula (HAELA)
against carbon tetrachloride (CCl4) and rifampicin-induced
hepatotoxicity in rats was evaluated and probable mechanism(s) of action has
been suggested. Administration of standard drug- silymarin and HAELA showed
significant hepatoprotection against CCl4 and rifampicin induced
hepatotoxicity in rats. Hepatoprotective activity of HAELA was due to the
decreased levels of serum marker enzymes viz., (AST, ALT, ALP and LDH) and
increased total protein including the improvement in histoarchitecture of liver
cells of the treated groups as compared to the control group. HAELA also showed
significant decrease in malondialdehyde (MDA) formation, increased activity of
non-enzymatic intracellular antioxidant, glutathione and enzymatic
antioxidants, catalase and superoxide dismutase. Results of this study demonstrated
that endogenous antioxidants and inhibition of lipid peroxidation of membrane
contribute to hepatoprotective activity of HAELA. |
| Page(s): | 822-829 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(08) [August 2010]
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