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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(08) [August 2010] >
| Title: | Antinociceptive activity of methanolic extract of leaves of Achyranthes aspera Linn. (Amaranthaceae) in animal models of nociception |
| Authors: | Barua, Chandana C
Talukdar, Archana
Begum, Shameem A
Lahon, Lalit C
Sarma, Dilip K
Pathak, Debesh C
Borah, Probodh |
| Keywords: | Achyranthes aspera
Hot plate
Nociception
Tail flick test
Writhing syndrome |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | Antinociceptive activity of methanolic extract of leaves of A. aspera was studied by peripheral/non-narcotic model of
nociception like acetic acid induced writhing syndrome test and central/narcotic
models like hot plate and tail flick tests. The methanolic extract of the
plant, administered orally (@ 300, 600 and 900 mg/kg, body weight) and the
standard drug (piroxicam; 10 mg/kg body weight, po) produced significant
analgesic activity in acetic acid induced writhing syndrome as compared to the
vehicle treated control group. In the hot plate analgesic test, in A. aspera at the above doses and the
standard drug treated group (morphine sulphate @ 1.5 mg/kg, ip), the duration
of reaction time (sec) increased dose dependently and significantly compared to
the control group. In the tail flick test, the
plant extract produced dose dependant increase in reaction time which was
significantly higher in the test and standard group compared to the control
group. The plant possesses significant antinociceptive property as evidenced in
all the animal models of nociception. It might possibly exert its effect
through diverse mechanism that may involve both central and peripheral
pathways. The preliminary phytochemical investigation revealed the presence of
steroids, alkaloids and triterpene in the methanolic extract of leaves of A. aspera which may be responsible for
its antinociceptive activity. |
| Page(s): | 817-821 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(08) [August 2010]
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