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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(08) [August 2010] >
| Title: | Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice |
| Authors: | Medhi, Bikash
Aggarwal, Raman
Chakrabarti, Amitava |
| Keywords: | Cerebral ischemia
Pioglitazone
PPAR- 
Neuroprotection |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | Present study was carried out to investigate
the possible neuroprotective effect of pioglitazone, an antidiabetic agent,
peroxisome proliferator-activated receptor (PPAR) agonist on acute phase
changes in mice model of cerebral ischemia induced by Bilateral Common Carotid
artery Occlusion (BCCAO). BCCAO model was used to induce partial global
cerebral ischemia. BCCAO induced significant brain infarct size and edema in
saline treated control group along with high increase in oxidative stress
showed by increase lipid peroxidation and decreased levels of antioxidants like
superoxide superoxide dismutage, catalase, glutathione peroxidase. Pioglitazone
(20 mg/kg, orally) administration showed neuroprotective effects by reducing
cerebral infarct size significantly as compared to control group. Postischemic
seizure susceptibility was also reduced as number of positive responders
decreased to a significant number. Brain edema was subsided to a significant
level. Pioglitazone reduced the plasma TNF- α levels as compared to ischemia
group significantly. Pioglitazone treatment also improved all the antioxidants
levels showing activity against oxidative stress induced by BCCAO. Pioglitazone
showed neuroprotection against ischemic insult suggesting the role of PPAR
agonist in neuroprotective agents. |
| Page(s): | 793-799 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(08) [August 2010]
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