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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(08) [August 2010] >
| Title: | In vitro effects of 5-hydroxytryptophan, indoleamines and leptin on arylalkylamine N-acetyltransferase (AA-NAT) activity in pineal organ of the fish, Clarias gariepinus (Burchell, 1822) during different phases of the breeding cycle |
| Authors: | Gupta, B B P
Yanthan, L
Singh, Ksh Manisana |
| Keywords: | AA-NAT
Breeding phase
5-HTP
Indoleamines
Leptin
Melatonin
Pinea |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | Arylalkylamine N-acetyltransferase (AA-NAT) is the
rate-limiting enzyme of melatonin biosynthetic pathway. In vitro effects of 5-hydroxytryptophan (5-HTP) and indoleamines
(serotonin, N-acetylserotonin and melatonin) were studied on AA-NAT activity in
the pineal organ of the fish, C.
gariepinus during different phases of its annual breeding cycle. Further, in vitro effects of leptin on AA-NAT
activity in the pineal organ were studied in fed and fasted fishes during
summer and winter seasons. Treatments with 5-HTP and indoleamines invariably stimulated
pineal AA-NAT activity in a dose-dependent manner during all the phases.
However, leptin increased AA-NAT
activity in a dose-dependent manner only in the pineal organ of the fed fishes, but not of the fasted
fishes irrespective of the seasons |
| Page(s): | 786-792 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(08) [August 2010]
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