Please use this identifier to cite or link to this item:
Title: In-vitro dissolution rate enhancement of poorly water soluble non-steroidal antiandrogen agent, bicalutamide, with hydrophilic carriers
Authors: Srikanth, M V
Babu, G V Murali Mohan
Sunil, S A
Rao, N Sreenivasa
Murthy, K V Ramana
Keywords: Bicalutamide;Dissolution rate;Poloxamer 407;Povidone K 30;Solid dispersion
Issue Date: Aug-2010
Publisher: CSIR
Abstract: This study presents dissolution rate enhancement of poorly water soluble antiandrogen agent, bicalutamide, using different solubilizing enhancers (Povidone K 30 and Poloxamer 407). Poloxamer 407 based dispersions exhibited higher dissolution ratethan Povidone K 30. Powder X-ray diffraction (PXRD) showed that degree of crystallinity decreased by increasing concentration of Povidone K 30 carrier. FTIR studies showed that drug used was compatible with carriers. Solid dispersion sprepared with povidone K30 changed crystalline form of drug to amorphous form.
Page(s): 629-634
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.69(08) [August 2010]

Files in This Item:
File Description SizeFormat 
Jsir 69(8) 629-634.pdf199.85 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.