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JSIR Vol.69(08) [August 2010] >

Title: In-vitro dissolution rate enhancement of poorly water soluble non-steroidal antiandrogen agent, bicalutamide, with hydrophilic carriers
Authors: Srikanth, M V
Babu, G V Murali Mohan
Sunil, S A
Rao, N Sreenivasa
Murthy, K V Ramana
Keywords: Bicalutamide
Dissolution rate
Poloxamer 407
Povidone K 30
Solid dispersion
Issue Date: Aug-2010
Publisher: CSIR
Abstract: This study presents dissolution rate enhancement of poorly water soluble antiandrogen agent, bicalutamide, using different solubilizing enhancers (Povidone K 30 and Poloxamer 407). Poloxamer 407 based dispersions exhibited higher dissolution ratethan Povidone K 30. Powder X-ray diffraction (PXRD) showed that degree of crystallinity decreased by increasing concentration of Povidone K 30 carrier. FTIR studies showed that drug used was compatible with carriers. Solid dispersion sprepared with povidone K30 changed crystalline form of drug to amorphous form.
Page(s): 629-634
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.69(08) [August 2010]

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