NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.69 [2010] >
JSIR Vol.69(08) [August 2010] >


Title: In-vitro dissolution rate enhancement of poorly water soluble non-steroidal antiandrogen agent, bicalutamide, with hydrophilic carriers
Authors: Srikanth, M V
Babu, G V Murali Mohan
Sunil, S A
Rao, N Sreenivasa
Murthy, K V Ramana
Keywords: Bicalutamide
Dissolution rate
Poloxamer 407
Povidone K 30
Solid dispersion
Issue Date: Aug-2010
Publisher: CSIR
Abstract: This study presents dissolution rate enhancement of poorly water soluble antiandrogen agent, bicalutamide, using different solubilizing enhancers (Povidone K 30 and Poloxamer 407). Poloxamer 407 based dispersions exhibited higher dissolution ratethan Povidone K 30. Powder X-ray diffraction (PXRD) showed that degree of crystallinity decreased by increasing concentration of Povidone K 30 carrier. FTIR studies showed that drug used was compatible with carriers. Solid dispersion sprepared with povidone K30 changed crystalline form of drug to amorphous form.
Page(s): 629-634
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.69(08) [August 2010]

Files in This Item:

File Description SizeFormat
Jsir 69(8) 629-634.pdf199.85 kBAdobe PDFView/Open
 Current Page Visits: 724 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 576722 since 06-Feb-2009  Last updated on 26-Aug-2014Webmaster: nopr@niscair.res.in