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IJC-B Vol.49B(07) [July 2010] >


Title: Microwave assisted transformation of benzimidazolyl chalcones into N1-substituted pyrazolines and evaluation of their antimicrobial activities
Authors: Rajora, Jayanti
Yadav, Janardan
Kumar, Ravindra
Srivastava, Yogendra K
Issue Date: Jul-2010
Publisher: CSIR
Abstract: 1-Benzimidazolyl-3-aryl-prop-2-ene-1-ones 2 have been transformed into N1-substituted pyrazoline derivatives by the interaction with phenyl hydrazine, thiosemicarbazide and hydrazine hydrate in the presence of formic acid under solvent free microwave induced protocol. The structure of newly synthesized compounds have been confirmed on the basis of their elemental analysis and spectral data. Newly synthesized compounds have been evaluated for their antimicrobial activity in vitro against E. coli, K. pneumonae, P. aeruginosa and B. subtilis using paper disc method. Some of the compounds have shown significant activity against the pathogens.
Page(s): 989-993
Source:IJC-B Vol.49B(07) [July 2010]

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