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|Title:||Microwave assisted transformation of benzimidazolyl chalcones into N<sup>1</sup>-substituted pyrazolines and evaluation of their antimicrobial activities|
Srivastava, Yogendra K
|Abstract:||1-Benzimidazolyl-3-aryl-prop-2-ene-1-ones <b style="">2</b> have been transformed into N<sup>1</sup>-substituted pyrazoline derivatives by the interaction with phenyl hydrazine, thiosemicarbazide and hydrazine hydrate in the presence of formic acid under solvent free microwave induced protocol. The structure of newly synthesized compounds have been confirmed on the basis of their elemental analysis and spectral data. Newly synthesized compounds have been evaluated for their antimicrobial activity <i style="">in vitro</i> against <i style="">E. coli, K. pneumonae, P. aeruginosa </i>and<i style=""> B. subtilis </i>using paper<i style=""> </i>disc method. Some of the compounds have shown significant activity against the pathogens.|
|Appears in Collections:||IJC-B Vol.49B(07) [July 2010]|
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