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Title: Synthesis and antimicrobial screening of some 3-[4-(3-aryl-1-phenyl-1H-pyrazol- 4-yl)-6-aryl-pyridin-2-yl] and 4-methyl- 3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins
Authors: Brahmbhatt, D I
Kaneria, Ankit R
Patel, Anil K
Patel, Niraj H
Keywords: Coumarin
pyridyl coumarin
3-substituted coumarin
6-substituted coumarin
pyrazolyl chalcone
Krohnke’s pyridine synthesis
Issue Date: Jul-2010
Publisher: CSIR
Abstract: Various 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyri­din-2-yl] coumarins 4a-l and 4-methyl-3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 5a-f  have been synthesized by reacting 3-coumarinoylmethyl pyridi­nium bromides 1a,b and 4-methyl-3-phenyl-6-coumarinoylmethyl pyridinium bromide 2 with pyrazolyl chalcones 3a-f respectively under Krohnke’s reaction conditions. All the synthesized compounds 4a-l and 5a-f have been screened for their antibacterial activity against Escherichia coli (Gram -ve bacteria), Bacillus subtillis (Gram +ve bacteria) and antifungal activity against Candida albican (Fungi).
Page(s): 971-977
Source:IJC-B Vol.49B(07) [July 2010]

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