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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(07) [July 2010] >
| Title: | Synthesis and antimicrobial screening of some 3-[4-(3-aryl-1-phenyl-1H-pyrazol- 4-yl)-6-aryl-pyridin-2-yl] and 4-methyl- 3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins |
| Authors: | Brahmbhatt, D I
Kaneria, Ankit R
Patel, Anil K
Patel, Niraj H |
| Keywords: | Coumarin
pyridyl coumarin
3-substituted coumarin
6-substituted coumarin
pyrazolyl chalcone
Krohnke’s pyridine synthesis |
| Issue Date: | Jul-2010 |
| Publisher: | CSIR |
| Abstract: | Various 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 4a-l and
4-methyl-3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 5a-f have been synthesized by reacting
3-coumarinoylmethyl pyridinium bromides 1a,b
and 4-methyl-3-phenyl-6-coumarinoylmethyl pyridinium bromide 2 with pyrazolyl chalcones 3a-f respectively under Krohnke’s
reaction conditions. All the synthesized compounds 4a-l and 5a-f have been
screened for their antibacterial activity against Escherichia coli (Gram -ve bacteria), Bacillus subtillis (Gram +ve bacteria) and antifungal activity
against Candida albican (Fungi). |
| Page(s): | 971-977 |
| Source: | IJC-B Vol.49B(07) [July 2010]
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