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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(07) [July 2010] >
| Title: | Synthetic and biological studies on some fused pyrazoles and their ethoxyphthalimide derivatives |
| Authors: | Joshi, Ajit
Sain, Devendra K
Thadhaney, Bhawana
Ojha, Swati
Hussain, Nasir
Talesara, Ganpat L |
| Keywords: | Antiviral study
cyclisation
nicotinohydrazide
phthalimidoxyethyl bromide |
| Issue Date: | Jul-2010 |
| Publisher: | CSIR |
| Abstract: |
Ethylacetoacetate reacts
with nicotinohydrazide in absolute ethanol to give
5-methyl-2-(pyridin-3-ylcarbonyl)-2,4-dihydro-3H-pyrazol-3-one 1 which upon condensation with various
aryl aldehydes affords the related arylidene derivatives 3a-d. Cyclisation reaction between hydrazine hydrate and compounds 3a-d yields 1-nicotinoyl-3-methyl-4-(4-substituted phenyl)-3a,4-dihydro pyrazolo[3,4-c]pyrazoles 4a-d. Subsequently title compounds 6a-d are obtained by reaction between compounds
4a-d and phthalimidoxyethyl bromide 5 in
presence of base. Final compounds have been screened for various cell cultures
of antimicrobial and antiviral testing with various expand standard drugs.
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| Page(s): | 965-970 |
| Source: | IJC-B Vol.49B(07) [July 2010]
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