NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(07) [July 2010] >


Title: Synthetic and biological studies on some fused pyrazoles and their ethoxyphthalimide derivatives
Authors: Joshi, Ajit
Sain, Devendra K
Thadhaney, Bhawana
Ojha, Swati
Hussain, Nasir
Talesara, Ganpat L
Keywords: Antiviral study
cyclisation
nicotinohydrazide
phthalimidoxyethyl bromide
Issue Date: Jul-2010
Publisher: CSIR
Abstract:  Ethylacetoacetate reacts with nicotinohydrazide in absolute ethanol to give 5-methyl-2-(pyridin-3-ylcarbonyl)-2,4-dihydro-3H-pyrazol-3-one 1 which upon condensation with various aryl aldehydes affords the related arylidene derivatives 3a-d. Cyclisation reaction between hydrazine hydrate and compounds 3a-d yields 1-nicotinoyl-3-methyl-4-(4-substituted phenyl)-3a,4-dihydro pyrazolo[3,4-c]pyrazoles 4a-d. Subsequently title compounds 6a-d are obtained by reaction between compounds 4a-d and phthalimidoxyethyl bromide 5 in presence of base. Final compounds have been screened for various cell cultures of antimicrobial and antiviral testing with various expand standard drugs.
Page(s): 965-970
Source:IJC-B Vol.49B(07) [July 2010]

Files in This Item:

File Description SizeFormat
IJCB 49B(7) 965-970.pdf114.13 kBAdobe PDFView/Open
 Current Page Visits: 842 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 606989 since 06-Feb-2009  Last updated on 31-Oct-2014Webmaster: nopr@niscair.res.in