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IJC-B Vol.49B [2010] >
IJC-B Vol.49B(07) [July 2010] >

Title: Synthetic and biological studies on some fused pyrazoles and their ethoxyphthalimide derivatives
Authors: Joshi, Ajit
Sain, Devendra K
Thadhaney, Bhawana
Ojha, Swati
Hussain, Nasir
Talesara, Ganpat L
Keywords: Antiviral study
phthalimidoxyethyl bromide
Issue Date: Jul-2010
Publisher: CSIR
Abstract:  Ethylacetoacetate reacts with nicotinohydrazide in absolute ethanol to give 5-methyl-2-(pyridin-3-ylcarbonyl)-2,4-dihydro-3H-pyrazol-3-one 1 which upon condensation with various aryl aldehydes affords the related arylidene derivatives 3a-d. Cyclisation reaction between hydrazine hydrate and compounds 3a-d yields 1-nicotinoyl-3-methyl-4-(4-substituted phenyl)-3a,4-dihydro pyrazolo[3,4-c]pyrazoles 4a-d. Subsequently title compounds 6a-d are obtained by reaction between compounds 4a-d and phthalimidoxyethyl bromide 5 in presence of base. Final compounds have been screened for various cell cultures of antimicrobial and antiviral testing with various expand standard drugs.
Page(s): 965-970
Source:IJC-B Vol.49B(07) [July 2010]

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