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Title: Synthetic and biological studies on some fused pyrazoles and their ethoxyphthalimide derivatives
Authors: Joshi, Ajit
Sain, Devendra K
Thadhaney, Bhawana
Ojha, Swati
Hussain, Nasir
Talesara, Ganpat L
Keywords: Antiviral study
phthalimidoxyethyl bromide
Issue Date: Jul-2010
Publisher: CSIR
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="metricconverter"> Ethylacetoacetate reacts with nicotinohydrazide in absolute ethanol to give 5-methyl-2-(pyridin-3-ylcarbonyl)-2,4-dihydro-3<i>H</i>-pyrazol-3-one <b style="">1</b> which upon condensation with various aryl aldehydes affords the related arylidene derivatives <b style="">3a-d</b>. Cyclisation reaction between<b style=""> </b>hydrazine hydrate and compounds <b style="">3a-d</b> yields 1-nicotinoyl-3-methyl-4-(4-substituted phenyl)-3<i style="">a</i>,4-dihydro pyrazolo[3,4-<i style="">c</i>]pyrazoles <b style="">4a-d</b>. Subsequently title compounds <b style="">6a-d</b> are obtained by reaction between compounds <b style="">4a-d</b> and phthalimidoxyethyl bromide <b style="">5 </b>in presence of base. Final compounds have been screened for various cell cultures of antimicrobial and antiviral testing with various expand standard drugs. </smarttagtype>
Description: 965-970
Appears in Collections:IJC-B Vol.49B(07) [July 2010]

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