NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(07) [July 2010] >


Title: Synthesis and characterization of some sulfonamide based bis-sydnones and their in vitro antimicrobial activity
Authors: Asundaria, Shahrukh T
Patel, Keshav C
Keywords: Synthesis
bis-sydnone
in vitro
mesoionic
pharmacological
Issue Date: Jul-2010
Publisher: CSIR
Abstract: 4-Sulfonamide substituted novel sydnones have been synthesized. The synthetic strategy utilizes 4,4′-diamino­diphenyl­sulfone as starting material to obtain the 3,3′-(sulfonyldi-4,1-phenylene)bis(4-chlorosulfonyl)sydnone 6 through several steps viz. esterification, hydrolysis (saponification), nitrosation, cyclisa­tion and chlorosulfonation, which are then condensed with different secondary amines to get final compounds. All new compounds have been characterized by spectral data as well as elemental analysis and have been tested for their antibacterial activity against gram positive S. pneumoniae and S. aureus, and gram negative bacteria E. coli and P. aeruginosa. Some of the synthesized compounds show excellent antimicrobial activity.
Page(s): 960-964
Source:IJC-B Vol.49B(07) [July 2010]

Files in This Item:

File Description SizeFormat
IJCB 49B(7) 960-964.pdf149.23 kBAdobe PDFView/Open
 Current Page Visits: 656 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 606222 since 06-Feb-2009  Last updated on 21-Oct-2014Webmaster: nopr@niscair.res.in