Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9933
Title: Synthesis and characterization of some sulfonamide based bis-sydnones and their <i style="">in vitro</i> antimicrobial activity
Authors: Asundaria, Shahrukh T
Patel, Keshav C
Keywords: Synthesis
bis-sydnone
<i style="">in vitro</i>
mesoionic
pharmacological
Issue Date: Jul-2010
Publisher: CSIR
Abstract: 4-Sulfonamide substituted novel sydnones have been synthesized. The synthetic strategy utilizes 4,4′-diamino­diphenyl­sulfone as starting material to obtain the 3,3′-(sulfonyldi-4,1-phenylene)bis(4-chlorosulfonyl)sydnone <b>6</b> through several steps <i style="">viz.</i> esterification, hydrolysis (saponification), nitrosation, cyclisa­tion and chlorosulfonation, which are then condensed with different secondary amines to get final compounds. All new compounds have been characterized by spectral data as well as elemental analysis and have been tested for their antibacterial activity against gram positive <i style="">S. pneumoniae</i> and <i style="">S. aureus</i>,<i style=""> </i>and gram negative bacteria <i style="">E. coli </i>and<i style=""> P. aeruginosa</i>. Some of the synthesized compounds show excellent antimicrobial activity.
Description: 960-964
URI: http://hdl.handle.net/123456789/9933
Appears in Collections:IJC-B Vol.49B(07) [July 2010]

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