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|Title:||Synthesis and characterization of some sulfonamide based bis-sydnones and their in vitro antimicrobial activity|
|Authors:||Asundaria, Shahrukh T|
Patel, Keshav C
|Abstract:||4-Sulfonamide substituted novel sydnones have been synthesized. The synthetic strategy utilizes 4,4′-diaminodiphenylsulfone as starting material to obtain the 3,3′-(sulfonyldi-4,1-phenylene)bis(4-chlorosulfonyl)sydnone 6 through several steps viz. esterification, hydrolysis (saponification), nitrosation, cyclisation and chlorosulfonation, which are then condensed with different secondary amines to get final compounds. All new compounds have been characterized by spectral data as well as elemental analysis and have been tested for their antibacterial activity against gram positive S. pneumoniae and S. aureus, and gram negative bacteria E. coli and P. aeruginosa. Some of the synthesized compounds show excellent antimicrobial activity.|
|Appears in Collections:||IJC-B Vol.49B(07) [July 2010]|
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