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|Title:||Synthesis and characterization of some sulfonamide based bis-sydnones and their <i style="">in vitro</i> antimicrobial activity|
|Authors:||Asundaria, Shahrukh T|
Patel, Keshav C
<i style="">in vitro</i>
|Abstract:||4-Sulfonamide substituted novel sydnones have been synthesized. The synthetic strategy utilizes 4,4′-diaminodiphenylsulfone as starting material to obtain the 3,3′-(sulfonyldi-4,1-phenylene)bis(4-chlorosulfonyl)sydnone <b>6</b> through several steps <i style="">viz.</i> esterification, hydrolysis (saponification), nitrosation, cyclisation and chlorosulfonation, which are then condensed with different secondary amines to get final compounds. All new compounds have been characterized by spectral data as well as elemental analysis and have been tested for their antibacterial activity against gram positive <i style="">S. pneumoniae</i> and <i style="">S. aureus</i>,<i style=""> </i>and gram negative bacteria <i style="">E. coli </i>and<i style=""> P. aeruginosa</i>. Some of the synthesized compounds show excellent antimicrobial activity.|
|Appears in Collections:||IJC-B Vol.49B(07) [July 2010]|
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