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Title: Synthesis and characterization of some sulfonamide based bis-sydnones and their in vitro antimicrobial activity
Authors: Asundaria, Shahrukh T
Patel, Keshav C
Keywords: Synthesis
in vitro
Issue Date: Jul-2010
Publisher: CSIR
Abstract: 4-Sulfonamide substituted novel sydnones have been synthesized. The synthetic strategy utilizes 4,4′-diamino­diphenyl­sulfone as starting material to obtain the 3,3′-(sulfonyldi-4,1-phenylene)bis(4-chlorosulfonyl)sydnone 6 through several steps viz. esterification, hydrolysis (saponification), nitrosation, cyclisa­tion and chlorosulfonation, which are then condensed with different secondary amines to get final compounds. All new compounds have been characterized by spectral data as well as elemental analysis and have been tested for their antibacterial activity against gram positive S. pneumoniae and S. aureus, and gram negative bacteria E. coli and P. aeruginosa. Some of the synthesized compounds show excellent antimicrobial activity.
Description: 960-964
Appears in Collections:IJC-B Vol.49B(07) [July 2010]

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