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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(07) [July 2010] >
| Title: | Synthesis and characterization of some sulfonamide based bis-sydnones and their in vitro antimicrobial activity |
| Authors: | Asundaria, Shahrukh T
Patel, Keshav C |
| Keywords: | Synthesis
bis-sydnone
in vitro
mesoionic
pharmacological |
| Issue Date: | Jul-2010 |
| Publisher: | CSIR |
| Abstract: | 4-Sulfonamide substituted
novel sydnones have been synthesized. The synthetic strategy utilizes 4,4′-diaminodiphenylsulfone
as starting material to obtain the 3,3′-(sulfonyldi-4,1-phenylene)bis(4-chlorosulfonyl)sydnone
6 through several steps viz.
esterification, hydrolysis (saponification), nitrosation, cyclisation and
chlorosulfonation, which are then condensed with different secondary amines to
get final compounds. All new compounds have been characterized by spectral data
as well as elemental analysis and have been tested for their antibacterial
activity against gram positive S. pneumoniae
and S. aureus, and gram negative bacteria E.
coli and P. aeruginosa. Some of
the synthesized compounds show excellent antimicrobial activity. |
| Page(s): | 960-964 |
| Source: | IJC-B Vol.49B(07) [July 2010]
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