|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(07) [July 2010] >
| Title: | Synthesis of novel benzimidazole  -keto sulfones and -hydroxy sulfones and their regiospecific alkylation studies |
| Authors: | Dubey, P K
Kumar, N D Mahesh
Chaitanya, M V S R K
Naidu, A
Vineel, B George |
| Keywords: | Benzimidazole
-keto sulfones
-hydroxy sulfones
H2O2
NaBH4
regiospecific
phase-transfer catalysis |
| Issue Date: | Jul-2010 |
| Publisher: | CSIR |
| Abstract: | The synthesis of benzimidazole β-keto
sulfides 5a-f by the reaction of N-alkyl-α-bromo-2-acetylbenzimidazoles
3a-b with 5-substituted-benzimidazole-2-thiols 4a-c followed by
successive oxidation with H2O2 to give β-keto sulfones 8a-f and reduction with NaBH4
to give β-hydroxy sulfones 9a-f is
described. Reaction of 5a, 8a, 9a and 10a with DMS in the presence of K2CO3 and
TBAB as PTC, resulted in the regiospecific N-methylation of
benzimidazole moiety of 12a, 11a, 14a and 13a respectively. |
| Page(s): | 937-943 |
| Source: | IJC-B Vol.49B(07) [July 2010]
|
|
