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Title: Synthesis, characterization and in vitro antimicrobial studies of new 2,3-disubstituted quinazolin-4(3H) ones of 2-[2-(2,6-dichlorophenyl)amino] phenyl acetic acid
Authors: Patel, Navin B
Shaikh, Asif R
Keywords: Antibacterial;antifungal;benzoxazinone;1, 3-oxazole;quinazolinone
Issue Date: Jul-2010
Publisher: CSIR
Abstract:  2-[2-(2,6-Dichlorophenyl)amino]phenylmethyl-3-{4-[(substituted phenyl)amino]-1,3-oxazol-2-yl}-]-6-bromoquinazo­lin-4(3H)ones 5a-o have been synthesized from the lead molecule 2-[(2,6-dichlorophenyl)amino]phenyl acetic acid 1, via carboxamide 4. Compound 4 on cyclization with substituted phenyl acetamide a-o gave desired compounds 5a-o. The title compounds have been characterized by elemental analysis, IR, 1H NMR and 13C NMR spectral data. All the compounds have been screened for antibacterial and antifungal activity.
Page(s): 929-936
Appears in Collections:IJC-B Vol.49B(07) [July 2010]

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