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IJC-B Vol.49B(07) [July 2010] >


Title: Synthesis of 2-(4-substitutedsulfonyl piperazin-1-yl-methyl)-3-aryl-quinazolin-4(3H)-one
Authors: Acharyulu, Palle V R
Dubey, P K
Reddy, P V V Prasada
Suresh, Thatipally
Keywords:  2-(Chloromethyl)-3-arylquinazolin-4(3H)-one
N-BOC piperazine
benzenesulfonyl chloride
methanesulfonyl chloride
Issue Date: Jul-2010
Publisher: CSIR
Abstract:  Reaction of 2-(chloromethyl)-3-arylquinazolin-4(3H)-one 3 with N-BOC piperazine 4 in acetonitrile using K2CO3 and KI, followed by deprotection of BOC group in IPA HCl, gives 3-aryl-2-(piperazin-1-yl)quinazolin-4(3H)-one 6. The latter on treatment with benzene/methane sulfonyl chloride in DCM in the presence of TEA at RT, results in the formation of 2-(4-benzene/methane sulfonylpiperazin-1-yl-methyl)-3-aryl-quinazolin-4(3H)-one 7. Alternatively, 7 can also be prepared from the reaction of 4-benzene/methane sulfonyl-piperazine 9 with 3, in the presence of K2CO3 and KI.
Page(s): 923-928
Source:IJC-B Vol.49B(07) [July 2010]

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