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dc.contributor.authorBhikshapathi, D V R N-
dc.contributor.authorKrishna, D R-
dc.contributor.authorKishan, V-
dc.date.accessioned2010-07-05T05:14:45Z-
dc.date.available2010-07-05T05:14:45Z-
dc.date.issued2010-07-
dc.identifier.issn0975-0967 (Online); 0972-5849 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/9883-
dc.description265-270en_US
dc.description.abstractBorrelidin, an antibiotic found to be an angiogenesis inhibitor, is a potential drug candidate due to its antiangiogenic activity and other biological activities. Keeping in view the scope of the antibiotic, we have performed some of the biological activities like effect of borrelidin on Mycobacterium tuberculosis H37Rv (ATCC 27294) by BACTEC 460 TB and multidrug resistant M. tuberculosis. In these studies, the minimum inhibitory concentration (MIC) of borrelidin against M. tuberculosis H37Rv was found to be 3.12 µg/mL. When compared with known antituberculous drugs like rifampicin, isoniazid, ethambutol and streptomycin, borrelidin showed higher MIC on M. tuberculosis H37Rv (ATCC 27294). The MIC was, however, lower than that of pyrazinamide. The inhibitory activity on multidrug resistant M. tuberculosis was, observed at 256 g/mL for borrelidin, rifampicin and isoniazid. The anti-HIV reverse transcriptase activity of borrelidin was tested by ELISA test, and mutagenic effect of borrelidin was performed by Ames test. Borrelidin showed moderate activity against anti-HIV reverse transcriptase enzyme. Results of Ames test indicated that borrelidin was non-mutagenic up to 500 g/mL concentration.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJBT Vol.9(3) [July 2010]en_US
dc.subjectBorrelidinen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectmutagenicityen_US
dc.subjectanti-HIV reverse transcriptase enzymeen_US
dc.titleAnti-HIV, anti-tubercular and mutagenic activities of borrelidinen_US
dc.typeArticleen_US
Appears in Collections:IJBT Vol.09(3) [July 2010]

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