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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.09 [2010] >
IJBT Vol.09(3) [July 2010] >
| Title: | Anti-HIV, anti-tubercular and mutagenic activities of borrelidin |
| Authors: | Bhikshapathi, D V R N
Krishna, D R
Kishan, V |
| Keywords: | Borrelidin
Mycobacterium tuberculosis
mutagenicity
anti-HIV reverse transcriptase enzyme |
| Issue Date: | Jul-2010 |
| Publisher: | CSIR |
| Abstract: | Borrelidin, an antibiotic found to be an angiogenesis inhibitor, is a
potential drug candidate due to its antiangiogenic activity and other
biological activities. Keeping in view the scope of the antibiotic, we have
performed some of the biological activities like effect of borrelidin on Mycobacterium tuberculosis H37Rv (ATCC 27294) by BACTEC
460 TB and multidrug resistant M. tuberculosis. In these studies, the
minimum inhibitory concentration (MIC) of borrelidin against
M. tuberculosis H37Rv was
found to be 3.12 µg/mL. When compared with known antituberculous drugs like
rifampicin, isoniazid, ethambutol and streptomycin, borrelidin showed higher
MIC on M. tuberculosis H37Rv
(ATCC 27294). The
MIC was, however, lower than that of pyrazinamide. The inhibitory activity on
multidrug resistant
M. tuberculosis was, observed at 256  g/mL
for borrelidin, rifampicin and isoniazid. The anti-HIV reverse transcriptase
activity of borrelidin was tested by ELISA test, and mutagenic effect of
borrelidin was performed by Ames test. Borrelidin showed moderate activity
against anti-HIV reverse transcriptase enzyme. Results of Ames test indicated
that borrelidin was non-mutagenic up to 500 g/mL concentration. |
| Page(s): | 265-270 |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.09(3) [July 2010]
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