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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.09 [2010] >
IJBT Vol.09(3) [July 2010] >
| Title: | Evolutionary interrelationships among polyomaviruses based on nucleotide and amino acid variations |
| Authors: | Bhattacharjee, Soumen |
| Keywords: | Large T-antigen (LTAg)
polyomavirus
viral protein 1 (VP1) |
| Issue Date: | Jul-2010 |
| Publisher: | CSIR |
| Abstract: | Polyomaviruses (PyVs), members of the family Polyomaviridae, are strictly vertebrate
resident viruses implicated in various pathogenic conditions including
neoplasias, especially in human. This study aims to review both nucleotide and
amino acid sequences of large T-antigen (LTAg), virion protein 1 (VP1) gene and
also whole genomes of all known PyVs till date, in ascertaining phylogenetic
relationships among themselves. The study detected genomic recombinations
within the oncoprotein LTAg coding sequences of PyV group, and identified
unique nucleotide and amino acid positions in the conserved regions of PyV-LTAg
coding sequence, which can facilitate strain differentiations in clinical
samples. |
| Page(s): | 252-264 |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.09(3) [July 2010]
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