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Title: In-vitro testing of anti-HIV activity of some medicinal plants
Authors: A Rege, Anuya
Y Ambaye, Ramkrishna
A Deshmukh, Ranjana
Keywords: Anti-HIV;Medicinal plant;Mangrove plants;Ocimum sanctum;Withania somnifera;Tinospora cordifolia;Avicennia officinalis;Rhizophora mucronata
Issue Date: Jun-2010
Publisher: CSIR
IPC Code: Int. cl.8—A61K 36/00, A61P 31/12, A61P 31/18.
Abstract: Medicinal plants namely Ocimum sanctum Linn., Withania somnifera Dunal, Tinospora cordifolia (Willd.) Miers. ex Hook.f. & Thoms., Avicennia officinalis Linn. and Rhizophora mucronata Lam. were screened for anti-HIV activity in the present study. O. sanctum, T. cordifolia, A. officinalis and R. mucronata showed anti-HIV potential by inhibiting the virus by 2 different mechanisms. Interference with the gp120/CD4 interaction and inhibition of viral Reverse Transcriptase (RT) contributed to the overall anti-viral activity in vitro. Among these plants A. officinalis and R. mucronata are mangrove plants and their medicinal properties are rarely reported.
Page(s): 193-199
Appears in Collections:IJNPR Vol.1(2) [June 2010]

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