Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9826
Title: Evaluation of antidiabetic activity of <i style="">Euphorbia hirta </i>Linn. in streptozotocin induced diabetic mice
Authors: Kumar, Sunil
Rashmi
Kumar, D
Keywords: <i style="">Euphorbia hirta</i>
Euphorbiaceae
<i style="">Dudhi</i>
Diabetes
Streptozotocin
Mice
Traditional medicine
Issue Date: Jun-2010
Publisher: CSIR
Series/Report no.: <b style=""> Int. cl.<sup>8</sup></b>—A61K 36/00, A61P 3/10
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"><smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="country-region"> <i style="">Euphorbia hirta</i> Linn. (Family-Euphorbiaceae) is widely used in traditional system of medicine to treat diabetes in India. The ethanolic extracts (250 and 500 mg/kg) of leaf, flower and stem were taken upundertaken to evaluate the antidiabetic activity against normal and streptozotocin (STZ) induced diabetic mice. Oral administration of the extracts for 21 days resulted in a significant reduction in blood glucose level. Chronic effects of the extracts on serum biochemistry were also studied and it was found that serum cholesterol, triglycerides, creatinine, urea, alkaline phosphatase levels were decreased significantly by all the extracts and Glibenclamide but HDL levels and total proteins were found to be increased after treatments. Thus, this study shows that<i style=""> E. hirta</i> has antidiabetic action and the extracts should further be subjected to bioactivity guided drug discovery to isolate a lead compound responsible for this activity. </smarttagtype></smarttagtype>
Description: 200-203
URI: http://hdl.handle.net/123456789/9826
Appears in Collections:IJNPR Vol.1(2) [June 2010]

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