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|Title: ||Evaluation of antidiabetic activity of Euphorbia hirta Linn. in streptozotocin induced diabetic mice|
|Authors: ||Kumar, Sunil|
|Keywords: ||Euphorbia hirta;Euphorbiaceae;Dudhi;Diabetes;Streptozotocin;Mice;Traditional medicine|
|Issue Date: ||Jun-2010|
|IPC Code: || Int. cl.8—A61K 36/00, A61P 3/10|
Euphorbia hirta Linn.
(Family-Euphorbiaceae) is widely used in traditional system of medicine to
treat diabetes in India.
The ethanolic extracts (250 and 500 mg/kg) of leaf, flower and stem were taken
upundertaken to evaluate the antidiabetic activity against normal and
streptozotocin (STZ) induced diabetic mice. Oral administration of the extracts
for 21 days resulted in a significant reduction in blood glucose level. Chronic
effects of the extracts on serum biochemistry were also studied and it was
found that serum cholesterol, triglycerides, creatinine, urea, alkaline
phosphatase levels were decreased significantly by all the extracts and
Glibenclamide but HDL levels and total proteins were found to be increased
after treatments. Thus, this study shows that E. hirta has antidiabetic action and the extracts should further
be subjected to bioactivity guided drug discovery to isolate a lead compound
responsible for this activity.
|Appears in Collections:||IJNPR Vol.1(2) [June 2010]|
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