23-May-2013
10:24:10 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.1 [2010] >
IJNPR Vol.1(2) [June 2010] >
| Title: | Biological activities of Kalmegh (Andrographis paniculata Nees) |
| Authors: | Niranjan, Abhishek
Tewari, SK
Lehri, Alok |
| Keywords: | Andrographis paniculata
Kalmegh
Maha-tita
Bhui-neem,
Acanthaceae
Andrographolides
Biological activities
Toxicity |
| Issue Date: | Jun-2010 |
| Publisher: | CSIR |
| IPC Code: | Int. cl.8—A61K 36/00, A61P 1/12, A61P 1/16, A61 P17/18, A61P 31/00, A61P 39/00. |
| Abstract: | Kalmegh (Andrographis paniculata Nees) has
wide range of medicinal and pharmacological applications. It is used in
different traditional systems of medicine and exhibits anti-inflammatory,
anti-HIV, antibacterial, antioxidant, antiparasitic, antispasmodic,
antidiabetic, anticarcinogenic, antipyretic, hepatoprotective, nematocidal and
various other activities. It is a potent scavenger of a variety of reactive
oxygen species (ROS) including superoxide anion, hydroxyl radical, singlet
oxygen, peroxynitrite and nitric oxide. Among several active chemical
constituents, andrographolide, neoandrographolide and dehydroandrographolide
are most important bioprotectants with wide range of therapeutic applications.
Andrographolides significantly inhibit the expression of iNOS, COX-2, mRNA,
protein, enzyme activity in RAW 264.7 macrophages that involves in
anti-inflammatory activity. Kalmegh
extract protects lipids, haemoglobin and red blood cells from lipid
peroxidation. It prevents oxidative damage and inhibits binding to toxic
metabolites to DNA. Safety evaluation studies indicate that kalmegh is well tolerated at very high
dose without any toxic effects. |
| Page(s): | 125-135 |
| Source: | IJNPR Vol.1(2) [June 2010]
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