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Title: Biological activities of Kalmegh (Andrographis paniculata Nees)
Authors: Niranjan, Abhishek
Tewari, SK
Lehri, Alok
Keywords: Andrographis paniculata; Kalmegh;Maha-tita;Bhui-neem,;Acanthaceae;Andrographolides;Biological activities;Toxicity
Issue Date: Jun-2010
Publisher: CSIR
IPC Code: Int. cl.8A61K 36/00, A61P 1/12, A61P 1/16, A61 P17/18, A61P 31/00, A61P 39/00.
Abstract: Kalmegh (Andrographis paniculata Nees) has wide range of medicinal and pharmacological applications. It is used in different traditional systems of medicine and exhibits anti-inflammatory, anti-HIV, antibacterial, antioxidant, antiparasitic, antispasmodic, antidiabetic, anticarcinogenic, antipyretic, hepatoprotective, nematocidal and various other activities. It is a potent scavenger of a variety of reactive oxygen species (ROS) including superoxide anion, hydroxyl radical, singlet oxygen, peroxynitrite and nitric oxide. Among several active chemical constituents, andrographolide, neoandrographolide and dehydroandrographolide are most important bioprotectants with wide range of therapeutic applications. Andrographolides significantly inhibit the expression of iNOS, COX-2, mRNA, protein, enzyme activity in RAW 264.7 macrophages that involves in anti-inflammatory activity. Kalmegh extract protects lipids, haemoglobin and red blood cells from lipid peroxidation. It prevents oxidative damage and inhibits binding to toxic metabolites to DNA. Safety evaluation studies indicate that kalmegh is well tolerated at very high dose without any toxic effects.
Page(s): 125-135
Appears in Collections:IJNPR Vol.1(2) [June 2010]

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