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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.47 [2010] >
IJBB Vol.47(3) [June 2010] >
| Title: | DNA degradation by aqueous extract of Aloe vera in the presence of copper ions |
| Authors: | Naqvi, Shoa
Ullah, M F
Hadi, S M |
| Keywords: | Copper
Aloe vera extract
Pro-oxidant action
Antioxidants
Apoptosis
DNA degradation |
| Issue Date: | Jun-2010 |
| Publisher: | CSIR |
| Abstract: | The plant Aloe vera has long been used in medicine, as dietary supplements
and for cosmetic purposes. Aloe vera extracts
are a rich source of polyphenols, such as aloin and aloe emodin and have shown
a wide range of pharmacological properties, including anti-inflammatory and
anti-cancer properties. The bioactive component aloe emodin has been reported
to induce apoptosis in various cancer cell lines. Many of the biological
activities of Aloe vera have been
attributed to its antioxidant properties. However, most plant-derived polyphenols
that are also present in Aloe vera may
exhibit pro-oxidant properties either alone or in the presence of transition
metals, such as copper. Previous reports from this laboratory have implicated
the pro-oxidant action as one of the mechanisms for their anti-cancer
properties. In the present paper, we show that aqueous extract of Aloe vera is also able to cause DNA
degradation in the presence of copper ions. Further, the extract is also able
to reduce Cu(II) to Cu(I) and generate reactive oxygen species, such as
superoxide anion and hydroxyl radicals in a dose-dependent manner, which
correlates with ability of the extract to cause DNA breakage. Thus, the study
shows that in addition to antioxidant activity, Aloe vera extract also possess pro-oxidant properties, leading to
oxidative DNA breakage. |
| Page(s): | 161-165 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.47(3) [June 2010]
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