|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(07) [July 2010] >
| Title: | Sub-chronic arsenic exposure aggravates nephrotoxicity in experimental diabetic rats |
| Authors: | Patel, Hitesh Vashrambhai
Kalia, Kiran |
| Keywords: | Arsenic
Diabetes mellitus
Oxidative stress
Renal tissue |
| Issue Date: | Jul-2010 |
| Publisher: | CSIR |
| Abstract: | The present experiment was planned to study
nephrotoxicity in experimental diabetic rats under sub-chronic exposure to
arsenic. Alloxan induced diabetic and control rats were exposed to sodium
arsenite (0 and 5.5 mg/kg, orally) for 30 days. More pronounced nephrotoxic
effects were noted in arsenic exposed diabetic group as evidenced by increased
blood urea nitrogen, serum creatinine and relative kidney weight and decreased
level of reduced glutathione and glutathione peroxidase activity compared to
non arsenic exposed diabetic group. Increased level of lipid peroxidation,
protein oxidation, superoxide dismutase and catalase activities under diabetic
condition remained unchanged in arsenic exposed diabetic group compared to
unexposed diabetic group. |
| Page(s): | 762-768 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(07) [July 2010]
|
|
