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|Title: ||Prophylactic efficacy of combination of DRDE-07 and its analogues with amifostine against sulphur mustard induced systemic toxicity|
|Authors: ||Gautam, Anshoo|
Pant, S C
|Issue Date: ||Jul-2010|
Sulphur mustard, [bis (2-chloroethyl)] sulphide (SM), is a bifunctional
alkylating agent. SM forms sulphonium ion in the body which alkylates DNA and
several other macromolecules, and induces oxidative stress. Although several
antidotes have been screened for the treatment of systemic toxicity of SM in
experimental animals none of them are recommended so far. In the search for
more effective and less toxic antidotes, various combinations were tried
against SM induced toxicity and skin lesions. SM exposed through percutaneous
route was used to evaluate the prophylactic efficacy of various combinations.
Low dose of DRDE-07 (S-2(2-aminoethylamino) ethyl phenyl sulphide), DRDE-30 [S-2(2-aminoethyl
amino) ethyl propyl sulphide], DRDE-35 [S-2(2-aminoethyl amino) ethyl butyl
sulphide] with amifostine combinations, were given orally 30 min prior to SM
exposure. Significant depletion was observed in body weight, organ body weight
index and hepatic GSH and GSSG content in mice after SM exposure. Pretreatment
with low dose of different combinations of DRDE-07, DRDE-30 and DRDE-35 with
amifostine could recover biochemical alterations and histopathological changes
caused by SM exposures.
|ISSN: ||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.48(07) [July 2010]|
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