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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(07) [July 2010] >
| Title: | Cyanide-induced changes in the levels of neurotransmitters in discrete brain regions of rats and their response to oral treatment with  -ketoglutarate |
| Authors: | Hariharakrishnan, Janardhanan
Satpute, Ravindra M
Bhattacharya, Rahul |
| Keywords: | Cyanide
Cyanide antidote
-Ketoglutarate
Neurotransmitters |
| Issue Date: | Jul-2010 |
| Publisher: | CSIR |
| Abstract: | Cyanide is a
potential suicidal, homicidal and chemical warfare agent. It produces histotoxic
hypoxia following inhibition of cytochrome c oxidase, a terminal respiratory
chain enzyme. The profound metabolic changes lead to neurotoxicity including
alterations in the levels of neurotransmitters. The present study addressed the
effect of acute exposure of lethal and sub-lethal doses of potassium cyanide
(KCN; 0.75 or 2.0 LD50; po)
on the levels of neurotransmitters in discrete brain regions of rats and its
response to treatment with a-ketoglutarate
(-KG; 0.5 g/kg; po; -10 min) alone or with sodium thiosulphate (STS; 1.0 g/kg; ip; -15
min). KCN
significantly decreased norepinephrine, dopamine and
5-hydroxytryptamine levels in different
brain regions which were resolved by a-KG and/or STS. Corpus striatum
and hippocampus were more sensitive as compared to cerebral cortex and
hypothalamus. -KG, a potential cyanide antidote alone
or with STS showed neuroprotective effects against cyanide. |
| Page(s): | 731-736 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(07) [July 2010]
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