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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(07) [July 2010] >
| Title: | Cellular and molecular mechanisms of dichlorvos neurotoxicity: Cholinergic, nonchlolinergic, cell signaling, gene expression and therapeutic aspects |
| Authors: | Binukumar, B K
Gill, K D |
| Keywords: | Behavioral
Dichlorvos
Neurotoxicity
Nicotinic receptors
Organophosphate |
| Issue Date: | Jul-2010 |
| Publisher: | CSIR |
| Abstract: | Inappropriate use of toxic chemicals is
common in developing countries, where it leads to excessive exposure and high
risks of unintentional poisoning. Risks are particularly high with the
pesticides used in agriculture, poor rural populations live and work in close
proximity to these compounds and often store these compounds in and around
their homes. It is estimated that most of the death from pesticide poisoning occur
in developing countries. Organophosphate insecticides have been extensively
used in agriculture in developing countries. Dichlorvos is a synthetic
insecticide and belongs to a family of chemically related organophosphate
pesticides (OP). Toxicity of dichlorvos has been documented in accidental human
poisoning, epidemiological studies, and animal models. In this review,
molecular mechanisms of dichlorvos neurotoxicity have been described. Usage, biotransformation, environmental levels, general population and occupational
exposure, effects on cell signaling receptors, mitochondrial metabolism,
oxidative stress and gene expression of
dichlorvos have been reviewed. Assessment of acute and chronic exposures
as well as neurotoxicity risk for lifetime exposures to dichlorvos have also
been considered. In addition special emphasis has been given to describe, the
role of dichlorvos in the chronic neurotoxicity and its molecular targets that
ultimately lead to neurodegeneration. |
| Page(s): | 697-709 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(07) [July 2010]
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