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Title: Synthesis, antimicrobial and insecticidal activity of some new cinnoline based chalcones and cinnoline based pyrazoline derivatives
Authors: Gautam, Nidhi
Chourasia, O P
Keywords: Cinnoline;chalcone;pyrazoline;antibacterial activity;antifungal activity;insecticidal activity
Issue Date: Jun-2010
Publisher: CSIR
Abstract:  4-Methyl-3-acetyl cinnoline used as a precursor to synthesize some new cinnoline based chalcones 3a-l. Reaction of chalcone with hydrazine hydrate in acetic acid yields the cinnoline based pyrazoline derivatives 4a-l. The structures of synthesized compounds have been confirmed by elemental analysis, IR and NMR spectral studies and  evaluated for their antibacterial activity against Bacillus subtilis, Escherichia coli, Staphylococcus aureaus and Klebsiella pneumoniae, antifungal activity against Aspergillus flavus, Fusarium oxysporum, Aspergillus niger and Trichoderma viridae and insecticidal activity against Periplaneta americana.
Page(s): 830-835
Appears in Collections:IJC-B Vol.49B(06) [June 2010]

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