|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(06) [June 2010] >
| Title: | Synthesis, characterization and biological screening of some novel tetrahydroquinazoline derivatives |
| Authors: | Dodiya, D K
Vaghasia, S J
Trivedi, A R
Ram, H K
Shah, V H |
| Keywords: | Tetrahydroquinazolines
antimicrobial activity
antitubercular activity |
| Issue Date: | Jun-2010 |
| Publisher: | CSIR |
| Abstract: | Synthesis of a series of
novel 4-aryl-5,5-dimethyl-7-(2′-piperidin-1′-yl-ethyl)-2-hydroxy-3,4,5,6-tetrahydroquinazolines
2a-i has been efficiently accomplished by condensation of 5,5,7-trimethyl-4-aryl-3,4,5,6-tetrahydroquinazolin-2-ols
1a-i with paraformaldehyde and piperidine in the presence of
conc. HCl. All the synthesized compounds have been characterized by
elemental analyses, IR, 1H NMR and mass spectroscopic investigation.
All the compounds 2a-i have been evaluated for
their antimicrobial and antitubercular activity. |
| Page(s): | 802-806 |
| Source: | IJC-B Vol.49B(06) [June 2010]
|
|
