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IJC-B Vol.49B [2010] >
IJC-B Vol.49B(06) [June 2010] >

Title: Synthesis, characterization and biological screening of some novel tetrahydroquinazoline derivatives
Authors: Dodiya, D K
Vaghasia, S J
Trivedi, A R
Ram, H K
Shah, V H
Keywords: Tetrahydroquinazolines
antimicrobial activity
antitubercular activity
Issue Date: Jun-2010
Publisher: CSIR
Abstract: Synthesis of a series of novel 4-aryl-5,5-dimethyl-7-(2′-piperidin-1′-yl-ethyl)-2-hydroxy-3,4,5,6-tetrahydroquinazolines 2a-i has been efficiently accomplished by condensation of 5,5,7-trimethyl-4-aryl-3,4,5,6-tetrahydroquinazolin-2-ols 1a-i with para­formaldehyde and piperidine in the presence of conc. HCl. All the synthesized compounds have been characterized by elemental analyses, IR, 1H NMR and mass spectroscopic investigation. All the compounds 2a-i have been evaluated for their antimicrobial and antitubercular activity.
Page(s): 802-806
Source:IJC-B Vol.49B(06) [June 2010]

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