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|Title:||Enantiospecific total synthesis of <i style="">ent</i>-5-senecioyloxy-10,11-epoxythapsan-10-ol|
|Abstract:||Enantiospecific total synthesis of optical antipode of the sesquiterpene 5-senecioyloxy-10,11-epoxythapsan-10-ol has been described. (<i style="">R</i>)-Carvone has been employed as the chiral starting material and a combination of intramolecular alkyation and Criegee fragmentation are employed for intramolecular stereospecific transfer of the chirality. An intramolecular diazoketone cyclopropanation and regioselective cyclopropane ring cleavage reactions have been employed for the creation of the three requisite contiguous quaternary carbon atoms.|
|Appears in Collections:||IJC-B Vol.49B(06) [June 2010]|
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