|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(06) [June 2010] >
| Title: | Enantiospecific total synthesis of ent-5-senecioyloxy-10,11-epoxythapsan-10-ol |
| Authors: | Srikrishna, A
Anebouselvy, K |
| Keywords: | Thapsia
thapsane
sesquiterpene
enantiospecific |
| Issue Date: | Jun-2010 |
| Publisher: | CSIR |
| Abstract: | Enantiospecific total synthesis of optical
antipode of the sesquiterpene 5-senecioyloxy-10,11-epoxythapsan-10-ol has been
described. (R)-Carvone has been
employed as the chiral starting material and a combination of intramolecular
alkyation and Criegee fragmentation are employed for intramolecular
stereospecific transfer of the chirality. An intramolecular diazoketone
cyclopropanation and regioselective cyclopropane ring cleavage reactions have
been employed for the creation of the three requisite contiguous quaternary
carbon atoms. |
| Page(s): | 776-788 |
| Source: | IJC-B Vol.49B(06) [June 2010]
|
|
