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Title: | The kinetic study on the effects of mixed aqueous-organic solvents on the rate of O- and N- cyclisation of N-(4'-nitrophenyl)phthalamic acid |
Authors: | Ahmad, Wan Hamdah Wan Ariffin, Azhar Khan, M Niyaz |
Issue Date: | Mar-2007 |
Publisher: | CSIR |
Abstract: | The pseudo-first-order rate constants (kobs) for the intramolecular carboxylic group-assisted cleavage of N-(4'-nitrophenyl)phthalamic acid (1) show nonlinear decrease of ~ 17-fold and ~ 117-fold with the increase in the respective contents of CH3CN (10-80% v/v) and 1,4-dioxan (9.5-79.4% v/v) in mixed aqueous solvents. The fraction of N-cyclization of 1 leading to the formation of N-(4'-nitrophenyl)phthalimide, 2, remains almost zero at ≤40% v/v CH₃CN while it increases from 0.06 to 0.49 with increase in CH₃CN content (50-80% v/v) at 1.0×10⁻³ M HCl. However, the observed data reveal an almost absence of N-cyclization within 1,4-dioxan content range 10-80% v/v. |
Page(s): | 416-421 |
URI: | http://hdl.handle.net/123456789/961 |
ISSN: | 0376-4710 |
Appears in Collections: | IJC-A Vol.46A(03) [March 2007] |
Files in This Item:
File | Description | Size | Format | |
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IJCA 46A(3) (2007) 416-421.pdf | 187.09 kB | Adobe PDF | View/Open |
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