NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.11 [2004] >
IJCT Vol.11(6) [November 2004] >


Title: Sensitive determination of atenolol in tablets using chloramine-T and two dyes
Authors: Basavaiah, K
Chandrashekar, U
Nagegowda, P
Keywords: Atenolol determination
indigo carmine
metanil yellow
titrimetry
spectrophotometry
Issue Date: Nov-2004
Publisher: CSIR
IPC CodeGO1J 3/00, GO1N 31/16
Abstract: Three methods, one titrimetric and two spectrophotometric, using chloramine-T (CAT) and two dyes, metanil yellow and indigocarmine have been developed for the determination of atenolol (ATN) in bulk drug and in tablets. The titrimetric method (Method A) involves the oxidation of the drug by a measured excess of CAT in acid medium followed by the determination of the residual oxidant by iodometric back titration. In spectrophotometric methods, ATN is oxidised by a known excess of CAT in acid medium followed by the determination of unreacted oxidant by reacting with a fixed amount of either metanil yellow (Method B) or indigo carmine (Method C) and measuring the increase in absorbance at 530 or 610 nm. Titrimetry is applicable in 3-20 mg range whereas in spectrophotometry, Beer's law is obeyed over the concentration ranges, 1-12 μg mL-1 (Method B) and 2.5 - 20.0 μg mL-1 (Method C). Molar absorptivity values as calculated from Beer's law data are found to be 1.19×104 L mol-1 cm-1 (Method B) and 6.65×103 L mol -1 cm-1 (Method C) and the corresponding Sandell sensitivity values are 0.022 and 0.040 μg cm-2. The choice of experimental conditions, which provide the maximum accuracy, precision and sensitivity, is discussed. The common excipients and additives found in tablet preparations did not interfere. The proposed methods were successfully applied to the determination of the drug in tablets. Recoveries ranged from 96.43 to 103.74 %. The utility and accuracy of the methods were further established by parallel determination by the official Indian Pharmacopoeial method and by recovery studies.
Page(s): 769-776
ISSN: 0975-0991 (Online); 0971-457X (Print)
Source:IJCT Vol.11(6) [November 2004]

Files in This Item:

File Description SizeFormat
IJCT 11(6) 769-776.pdf208 kBAdobe PDFView/Open
 Current Page Visits: 570 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 573004 since 06-Feb-2009  Last updated on 26-Aug-2014Webmaster: nopr@niscair.res.in