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Title: Investigation on the wound healing activity of Tilvadi ghrita : a herbal formulation
Authors: Charde, M S
Hemke, A T
Fulzele, S V
Satturwar, P M
Kasture, A V
Dorle, A K
Keywords: Tilvadi ghrita
Wound healing activity
Herbal formulation
Issue Date: Jul-2004
Publisher: CSIR
IPC Code Int Cl.7:A61K 35/78, A61K 35/20, A61P 29/00, A61P 17/02, A61P 31/02
Abstract: Tilvadi ghrita (TG) is a ghee-based herbal formulation claimed to promote wound healing in traditional practices. However no systematic studies are reported in modern scientific literature with regard to the verification of the traditional medicinal claims of TG. The present study was undertaken to investigate and rationalize the wound healing activity of TG in experimental rats. Tilvadi ghrita increased the tensile strength which is significantly improved over the untreated wounds. Promotion of tensile strength demonstrates wound healing potential of TG in incision wound which may probably be due to promotion of collagenation. This data is further supported by observation of histopathological response in healed tissues which reveal that TG promotes keratinization, epithelization, collagenation and fibrosis. TG also demonstrates its healing potential in excision wound model with significant reduction in wound contraction area with faster healing.
Page(s): 247-252
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Source:IJTK Vol.03(3) [July 2004]

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