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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(12) December 2005] >
| Title: | Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of 3,5-dimethyl pyrazoles, 3-methyl pyrazol-5-ones and 3,5-disubstituted pyrazolines |
| Authors: | Amir, Mohd
Kumar, Shikha |
| Keywords: | Dimethyl pyrazole
disubstituted pyrazolines
anti-inflammatory
analgesic activity
ulcerogenic activity
lipid peroxidation
diclofenac
ibuprofen
flurbiprofen
2,4-dichlorophenoxy acetic acid |
| Issue Date: | Dec-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D |
| Abstract: | 3,5-Dimethyl pyrazole 3a-d and 3-methyl pyrazol-5-one 4a-d derivatives of diclofenac, ibuprofen, flurbiprofen and 2,4-dichlorophenoxy
acetic acid have been synthesized. In addition, substituted pyrazoline
derivatives of ibuprofen 6a-e have
also been prepared by treating different chalcones 5a-e with ibuprofen hydrazide. Some of the newly synthesized
compounds are screened for anti-inflammatory activity and few compounds showing
80% activity are selected for analgesic, ulcerogenic and lipid peroxidation
activities. |
| Page(s): | 2532-2537 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(12) December 2005]
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