Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9243
Title: Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of 3,5-dimethyl pyrazoles, 3-methyl pyrazol-5-ones and 3,5-disubstituted pyrazolines
Authors: Amir, Mohd
Kumar, Shikha
Keywords: Dimethyl pyrazole
disubstituted pyrazolines
anti-inflammatory
analgesic activity
ulcerogenic activity
lipid peroxidation
diclofenac
ibuprofen
flurbiprofen
2,4-dichlorophenoxy acetic acid
Issue Date: Dec-2005
Publisher: CSIR
Series/Report no.: Int.Cl.7 C 07 D
Abstract: 3,5-Dimethyl pyrazole 3a-d and 3-methyl pyrazol-5-one 4a-d derivatives of diclofenac, ibuprofen, flurbiprofen and 2,4-dichlorophenoxy acetic acid have been synthesized. In addition, substituted pyrazoline derivatives of ibuprofen 6a-e have also been prepared by treating different chalcones 5a-e with ibuprofen hydrazide. Some of the newly synthesized compounds are screened for anti-inflammatory activity and few compounds showing 80% activity are selected for analgesic, ulcerogenic and lipid peroxidation activities.
Description: 2532-2537
URI: http://hdl.handle.net/123456789/9243
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(12) December 2005]

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