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IJC-B Vol.44B [2005] >
IJC-B Vol.44B(12) December 2005] >


Title: Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of 3,5-dimethyl pyrazoles, 3-methyl pyrazol-5-ones and 3,5-disubstituted pyrazolines
Authors: Amir, Mohd
Kumar, Shikha
Keywords: Dimethyl pyrazole
disubstituted pyrazolines
anti-inflammatory
analgesic activity
ulcerogenic activity
lipid peroxidation
diclofenac
ibuprofen
flurbiprofen
2,4-dichlorophenoxy acetic acid
Issue Date: Dec-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D
Abstract: 3,5-Dimethyl pyrazole 3a-d and 3-methyl pyrazol-5-one 4a-d derivatives of diclofenac, ibuprofen, flurbiprofen and 2,4-dichlorophenoxy acetic acid have been synthesized. In addition, substituted pyrazoline derivatives of ibuprofen 6a-e have also been prepared by treating different chalcones 5a-e with ibuprofen hydrazide. Some of the newly synthesized compounds are screened for anti-inflammatory activity and few compounds showing 80% activity are selected for analgesic, ulcerogenic and lipid peroxidation activities.
Page(s): 2532-2537
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(12) December 2005]

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