Please use this identifier to cite or link to this item:
Title: 7-[(4-Substituted phenyl-piperazin-1-yl)-alkoxyl]-4-methylchromene-2-ones as potential atypical antipsychotics: Synthesis and pharmacological evaluation
Authors: Shelke, S M
Sati, Nitin
Veer, V S
Bhosale, S H
Bodhankar, S L
Mahadik, K R
Kadam, S S
Keywords: Substituted methylchromenones
pharmacological evaluation
dichlorophenyl piperazines
Issue Date: Nov-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D // A 61 P/28</b>
Abstract: 7-Hydroxy-4-methylchromene-2-one <b style="">1</b> when reacted respectively with 2-bromo-1-chloroethane and 3-bromo-1-chloropropane in acetonitrile and in the presence of anhydrous K<sub>2</sub>CO<sub>3</sub> yields 7-alkoxy-4-methylchromene-2-ones <b style="">2a,b</b>. Compounds <b style="">2a,b</b> when refluxed with various arylpiperazines in toluene and in the presence of triethylamine yield the title compounds, 7-[(4-substituted phenyl-piperazin-1-yl)-alkoxyl]-4-methylchromen-2-ones <b style="">3a-j</b>.Their atypical antipsychotic activity have been evaluated by their ability to inhibit apomorphine induced climbing behavior (D<sub>2</sub> antagonism) and to inhibit the 5–HTP induced head twitches in albino mice (5-HT<sub>2A</sub> antagonism) alongwith catalepsy studies. All the compounds inhibit apomorphine induced climbing behavior and 5-HTP induced head twitches. The SAR studies reveal that methyl group in the phenyl ring of piperazine and the chain length (n=3) gives more dopaminergic and serotonergic antagonistic activity, while dichlorophenyl piperazines have less dopaminergic and serotonergic antagonistic activity. <b style="">3f</b> and <b style="">3g</b> have been found to have significant atypical behaviour.
Description: 2295-2300
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(11) [November 2005]

Files in This Item:
File Description SizeFormat 
IJCB 44B(11) 2295-2300.pdf145.84 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.