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Title: Synthesis and antihypertensive activity of new 1,4-dihydropyridines
Authors: Hadizadeh, Farzin
Hassanabad, Zahra Fatehi
Bamshad, Mohammad
Poorsoghat, Hamed
Hassanabad, Mohammad Fatehi
Keywords: antihypertensive activity;1,4-dihydropyridines;imidazole;desoxycorticosterone acetate
Issue Date: Nov-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D//A 61 P 9/12
Abstract: A series of 1,4-dihydropyridines bearing dimethylamino 2a-f or 1H-imidazol-1-yl 3a-f side chain in the 2 position have been synthesized from unsubstituted ones 1a-f and tested for antihypertensive activity in desoxycorticosterone acetate (DOCA)-induced hypertensive rats. All the compounds have been found to be less active than nifedipine.
Page(s): 2343-2347
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(11) [November 2005]

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