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Title: Stereoselective synthesis of the enantiomer of the fatty acid component of the potent immunosuppressant, stevastelin
Authors: Raghavan, Sadagopan
Reddy, S Ramakrishna
Rajitha, B
Keywords: Stereoselective synthesis;enantiomer;fatty acid;immunosuppressant;stevastelin;dimethylcuprate;epoxy alcohol;Grignard reaction
Issue Date: Nov-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 C, C 07 D // A 61 P 37/06
Abstract: A stereoselective synthesis of the enantiomer of the fatty acid chain of stevastelin is disclosed. The C4 methyl group is introduced regio- and stereoselectively via dimethylcuprate opening of epoxy alcohol while the C5 stereogenic center was introduced in a highly stereoselective fashion by Grignard reaction.
Page(s): 2314-2321
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(11) [November 2005]

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