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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(11) [November 2005] >
| Title: | Stereoselective synthesis of the enantiomer of the fatty acid component of the potent immunosuppressant, stevastelin |
| Authors: | Raghavan, Sadagopan
Reddy, S Ramakrishna
Rajitha, B |
| Keywords: | Stereoselective synthesis
enantiomer
fatty acid
immunosuppressant
stevastelin
dimethylcuprate
epoxy alcohol
Grignard reaction |
| Issue Date: | Nov-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 C, C 07 D // A 61 P 37/06 |
| Abstract: | A stereoselective synthesis of the
enantiomer of the fatty acid chain of stevastelin is disclosed. The C4 methyl
group is introduced regio- and stereoselectively via dimethylcuprate opening of
epoxy alcohol while the C5 stereogenic center was introduced in a highly
stereoselective fashion by Grignard reaction. |
| Page(s): | 2314-2321 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(11) [November 2005]
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