Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9217
Title: Microwave irradiated high-speed solution synthesis of peptide acids employing Fmoc-amino acid pentafluorophenyl esters as coupling agents
Authors: Babu, Vommina V Suresh
Rao, R V Ramana
Keywords: Peptide acids
microwave
Fmoc
pentafluorophenyl esters
coupling agents
Issue Date: Nov-2005
Publisher: CSIR
Series/Report no.: <b>Int.Cl.<sup>7</sup> C 07 K</b>
Abstract: A high-speed solution phase synthesis of peptide acids employing commercially available Fmoc-amino acid pentafluorophenyl esters as coupling agents has been demonstrated. The coupling has been found to be fast and completed in 30-45 sec. A simple work-up of the reaction mixture has resulted <i>N</i>-protected peptide acids in good yield. Utilizing the present method, the coupling of difficult sequences containing highly hindered <img src='/image/spc_char/alpha.gif' border=0> , <img src='/image/spc_char/alpha.gif' border=0>-dialkyl amino acids has also been demonstrated. Further, the synthesis of diastereomeric dipeptides, Fmoc-Phg-Phe-OMe and Fmoc-D-Phg-Phe-OMe revealed that the coupling is free from racemization.
Description: 2328-2332
URI: http://hdl.handle.net/123456789/9217
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(11) [November 2005]

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