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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(11) [November 2005] >
| Title: | Microwave irradiated high-speed solution synthesis of peptide acids employing Fmoc-amino acid pentafluorophenyl esters as coupling agents |
| Authors: | Babu, Vommina V Suresh
Rao, R V Ramana |
| Keywords: | Peptide acids
microwave
Fmoc
pentafluorophenyl esters
coupling agents |
| Issue Date: | Nov-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 K |
| Abstract: | A high-speed solution phase synthesis of
peptide acids employing commercially available Fmoc-amino acid
pentafluorophenyl esters as coupling agents has been demonstrated. The coupling
has been found to be fast and completed in 30-45 sec. A simple work-up of the
reaction mixture has resulted N-protected peptide acids in good yield.
Utilizing the present method, the coupling of difficult sequences containing
highly hindered  , -dialkyl amino acids has also been demonstrated. Further,
the synthesis of diastereomeric dipeptides, Fmoc-Phg-Phe-OMe and Fmoc-D-Phg-Phe-OMe revealed that
the coupling is free from racemization. |
| Page(s): | 2328-2332 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(11) [November 2005]
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