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Title: Microwave irradiated high-speed solution synthesis of peptide acids employing Fmoc-amino acid pentafluorophenyl esters as coupling agents
Authors: Babu, Vommina V Suresh
Rao, R V Ramana
Keywords: Peptide acids;microwave;Fmoc;pentafluorophenyl esters;coupling agents
Issue Date: Nov-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 K
Abstract: A high-speed solution phase synthesis of peptide acids employing commercially available Fmoc-amino acid pentafluorophenyl esters as coupling agents has been demonstrated. The coupling has been found to be fast and completed in 30-45 sec. A simple work-up of the reaction mixture has resulted N-protected peptide acids in good yield. Utilizing the present method, the coupling of difficult sequences containing highly hindered , -dialkyl amino acids has also been demonstrated. Further, the synthesis of diastereomeric dipeptides, Fmoc-Phg-Phe-OMe and Fmoc-D-Phg-Phe-OMe revealed that the coupling is free from racemization.
Page(s): 2328-2332
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(11) [November 2005]

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