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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(11) [November 2005] >
| Title: | Synthesis and preliminary anticancer activity of new 1H-4,5-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-1,2,4-triazoline-5-thiones. Part II |
| Authors: | Dogan, H Nese
Duran, Arzu
Rollas, Sevim |
| Keywords: | 1H-4,5-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-1,2,4-triazoline-5-thiones
anticancer activity |
| Issue Date: | Nov-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D // A 61 P 35/02 |
| Abstract: | The compounds 1H-4,5-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-1,2,4-triazoline-5-thiones
have been synthesised from 3-hydroxy-2-naphthoic acid hydrazide in two steps.
The structural elucidation of the synthesised compounds has been performed by 1H
NMR and mass spectroscopic data besides elemental analyses. Some of the
compounds are tested in vitro for
their ability to inhibit growth of 60 different human cancer cell lines by the
National Cancer Institute and notable cytotoxic effect on some cancer cell
lines is observed from some of them as expected in comparison with the control
agent 5-fluorouracil. |
| Page(s): | 2301-2307 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(11) [November 2005]
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