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Title: Synthesis and preliminary anticancer activity of new 1<i style="">H</i>-4,5-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-1,2,4-triazoline-5-thiones. Part II
Authors: Dogan, H Nese
Duran, Arzu
Rollas, Sevim
Keywords: 1<i style="">H</i>-4,5-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-1,2,4-triazoline-5-thiones
anticancer activity
Issue Date: Nov-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D // A 61 P 35/02</b>
Abstract: The compounds 1<i style="">H</i>-4,5-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-1,2,4-triazoline-5-thiones have been synthesised from 3-hydroxy-2-naphthoic acid hydrazide in two steps. The structural elucidation of the synthesised compounds has been performed by <sup>1</sup>H NMR and mass spectroscopic data besides elemental analyses. Some of the compounds are tested <i style="">in vitro</i> for their ability to inhibit growth of 60 different human cancer cell lines by the National Cancer Institute and notable cytotoxic effect on some cancer cell lines is observed from some of them as expected in comparison with the control agent 5-fluorouracil.
Description: 2301-2307
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(11) [November 2005]

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