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IJC-B Vol.44B(10) [October 2005] >


Title: Synthesis and antimicrobial screening of 2'-hydroxy-5'-(phenylazo)-N- (1", 3"-diketo­phenylamine)-3-chloroazetidin-2-ones
Authors: Halve, Anand K
Gour, Poonam
Dubey, Rakesh
Bhadauria, Deepti
Bhaskar, Bhuwan
Keywords: Chloroazetidin-2-ones
A. niger
C. albicans
Fluconazole
Issue Date: Oct-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D // A 61 P 31/04
Abstract: Some new 2'-hydroxy-5'-(phenylazo)-N- (1",3"-diketo­phenyl­amine)-3-chloroazetidin -2-ones 2a-l have been synthesized and their structures have been established on the basis of their elemental analysis and spectroscopic data. Compounds 2e, j and l show significant antibacterial and antifungal activity. 2'-hydroxy-5'(p-chlorophenylazo)-N-(1", 3"-diketo-p-chlorophenylamine)-3-chloroazetidin-2-one 2l has been found to be a more potent anti­fungal agent against A. niger and C. albicans as compared to the control drug-Fluconazole.
Page(s): 2163-2165
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(10) [October 2005]

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