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Title: Synthesis and antimicrobial screening of 2'-hydroxy-5'-(phenylazo)-N- (1", 3"-diketo­phenylamine)-3-chloroazetidin-2-ones
Authors: Halve, Anand K
Gour, Poonam
Dubey, Rakesh
Bhadauria, Deepti
Bhaskar, Bhuwan
Keywords: Chloroazetidin-2-ones
<i>A. niger</i>
<i>C. albicans</i>
Issue Date: Oct-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D // A 61 P 31/04</b>
Abstract: Some new 2'-hydroxy-5'-(phenylazo)-N- (1",3"-diketo­phenyl­amine)-3-chloroazetidin -2-ones <b>2a-l</b> have been synthesized and their structures have been established on the basis of their elemental analysis and spectroscopic data. Compounds <b>2e, j</b> and <b>l</b> show significant antibacterial and antifungal activity. 2'-hydroxy-5'(<i>p</i>-chlorophenylazo)-N-(1", 3"-diketo-<i>p</i>-chlorophenylamine)-3-chloroazetidin-2-one <b>2l</b> has been found to be a more potent anti­fungal agent against <i>A. niger</i> and <i>C. albicans</i> as compared to the control drug-Fluconazole.
Description: 2163-2165
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(10) [October 2005]

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