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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(10) [October 2005] >
| Title: | Rapid and efficient synthesis of some biological active 2-azetidinones under microwave irradiation |
| Authors: | Desai, K G
Desai, K R |
| Keywords: | Schiffbases
2-azetidinones
microwave technique (MWI)
antimicrobial activity evaluation |
| Issue Date: | Oct-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D // A 61 P 31/04, 31/10 |
| Abstract: | An efficient and extremely fast procedure
for the synthesis of
4-aryl-3-chloro-1-[(2-benzothiazolylthio)acetamidyl]-2-azetidinone 4 by
the reaction of arylidene-[(2-benzothiazolylthio)acetamidyl] 3 with
chloroacetylchloride in DMF in the presence of catalytic amount of
triethylamine under microwave irradiation is described. A considerable increase
in the reaction rate has been observed with better yield. All the compounds
have been screened for their antifungal activity against Candida albicans
and Aspergillus niger, andÂ
antibacterial activity against Escherchia coli, Staphylococcus
aureus and Bacills substilis. In the primary screening, some of the
compounds exhibit appreciable activity. The structures of the synthesised
compounds 4a-j have been characterized on the basis of their elemental
analysis and spectral data. |
| Page(s): | 2093-2096 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(10) [October 2005]
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