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Title: Rapid and efficient synthesis of some biological active 2-azetidinones under microwave irradiation
Authors: Desai, K G
Desai, K R
Keywords: Schiffbases;2-azetidinones;microwave technique (MWI);antimicrobial activity evaluation
Issue Date: Oct-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D // A 61 P 31/04, 31/10
Abstract: An efficient and extremely fast procedure for the synthesis of 4-aryl-3-chloro-1-[(2-benzothiazolylthio)acetamidyl]-2-azetidinone 4 by the reaction of arylidene-[(2-benzothiazolylthio)acetamidyl] 3 with chloroacetylchloride in DMF in the presence of catalytic amount of triethylamine under microwave irradiation is described. A considerable increase in the reaction rate has been observed with better yield. All the compounds have been screened for their antifungal activity against Candida albicans and Aspergillus niger, and  antibacterial activity against Escherchia coli, Staphylococcus aureus and Bacills substilis. In the primary screening, some of the compounds exhibit appreciable activity. The structures of the synthesised compounds 4a-j have been characterized on the basis of their elemental analysis and spectral data.
Page(s): 2093-2096
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(10) [October 2005]

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