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Title: Rapid and efficient synthesis of some biological active 2-azetidinones under microwave irradiation
Authors: Desai, K G
Desai, K R
Keywords: Schiffbases
microwave technique (MWI)
antimicrobial activity evaluation
Issue Date: Oct-2005
Publisher: CSIR
Series/Report no.: <b>Int.Cl.<sup>7</sup> C 07 D // A 61 P 31/04, 31/10</b>
Abstract: An efficient and extremely fast procedure for the synthesis of 4-aryl-3-chloro-1-[(2-benzothiazolylthio)acetamidyl]-2-azetidinone <b>4</b> by the reaction of arylidene-[(2-benzothiazolylthio)acetamidyl] <b>3</b> with chloroacetylchloride in DMF in the presence of catalytic amount of triethylamine under microwave irradiation is described. A considerable increase in the reaction rate has been observed with better yield. All the compounds have been screened for their antifungal activity against <i>Candida albicans</i> and <i>Aspergillus niger</i>, and  antibacterial activity against <i>Escherchia coli</i>, <i>Staphylococcus aureus</i> and <i>Bacills substilis</i>. In the primary screening, some of the compounds exhibit appreciable activity. The structures of the synthesised compounds <b>4a-j</b> have been characterized on the basis of their elemental analysis and spectral data.
Description: 2093-2096
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(10) [October 2005]

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