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Title: Clean and efficient microwave solvent-free synthesis of some antimicrobial compounds from 2-aminothiadiazine
Authors: Patel, V M
Desai, K R
Keywords: Microwave irradiation;antimicrobial activity;2-aminothiadiazine
Issue Date: Oct-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D // A 61 P 31/04
Abstract: A series of 1-[5΄-(2, 4-dichloro-5-fluorophenyl)-6΄H-1΄, 3΄, 4΄-thiadiazin-2΄-yl]-4-(substituted phenyl)-3-chloro-2-oxo-azetidines 3 and 3-[5΄-(2, 4-dichloro-5-fluorophenyl)-6΄H-1΄,3΄,4΄-thia­diazin-2΄-yl]-2-(substituted phenyl)-1, 3-thiazolidin-4-one 4 have been synthesized using environmentally benign procedure and evaluated for their antimicrobial activity. Neat reactants are subjected to microwave irradiation under solvent-free condition. The observed yields and enhancement in reaction rates are due to the solvent-free conditions coupled with microwave usage. Structures of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data.
Page(s): 2158-2162
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(10) [October 2005]

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