|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(10) [October 2005] >
| Title: | Synthesis and biological activity of some 3-imidazo[1,2- ]pyridin-2-yl-chromen-2-one and 3-indolizin-2-yl-chromen-2-one |
| Authors: | Kumar, P Vijaya
Rao, V Rajeswar |
| Keywords: | Coumarins
aminopyridines
cyclization reaction
indolizines
antitubercular
antiviral
anticancer |
| Issue Date: | Oct-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 209/04 // A 61 P 31/06, 31/12, 35/00 |
| Abstract: | Condensation of 3-(2-bromoacetyl)coumarins 1
with various 2-aminopyridines 2 in
the solid state under solvent-free conditions yield 3-imidazo[1,2- ]pyridin-2-yl-chromen-2-ones
3. Condensation of 1 with 2-methylpyridines in dry benzene
affords N-alkylpyridinium salts 5.
These undergo cyclization reaction when heated with sodium bicarbonate to give
indolizines 6. The structures of
newly prepared compounds have been confirmed from analytical and spectral data.
Some of the compounds exhibit antitubercular, antiviral and anticancer
activities. |
| Page(s): | 2120-2125 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(10) [October 2005]
|
|
