Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9203
Title: Synthesis and biological activity of some 3-imidazo[1,2-<i><img src='/image/spc_char/alpha.gif' border=0></i>]pyridin-2-yl-chromen-2-one and 3-indolizin-2-yl-chromen-2-one
Authors: Kumar, P Vijaya
Rao, V Rajeswar
Keywords: Coumarins
aminopyridines
cyclization reaction
indolizines
antitubercular
antiviral
anticancer
Issue Date: Oct-2005
Publisher: CSIR
Series/Report no.: Int.Cl.<sup>7</sup> C 07 D 209/04 // A 61 P 31/06, 31/12, 35/00
Abstract: Condensation of 3-(2-bromoacetyl)coumarins <b>1</b> with various 2-aminopyridines <b style="">2</b> in the solid state under solvent-free conditions yield 3-imidazo[1,2-<i><img src='/image/spc_char/alpha.gif' border=0> </i>]pyridin-2-yl-chromen-2-ones <b style="">3</b>. Condensation of <b style="">1</b> with 2-methylpyridines in dry benzene affords N-alkylpyridinium salts <b style="">5</b>. These undergo cyclization reaction when heated with sodium bicarbonate to give indolizines <b style="">6</b>. The structures of newly prepared compounds have been confirmed from analytical and spectral data. Some of the compounds exhibit antitubercular, antiviral and anticancer activities.
Description: 2120-2125
URI: http://hdl.handle.net/123456789/9203
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(10) [October 2005]

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