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|Title:||Synthesis and antibacterial evaluation of some theophylline derivatives|
Talesara, G L
|Series/Report no.:||Int.Cl.7 C 07 D // A 61 P 31/04|
|Abstract:||Some novel antiasthmatic theophylline derivatives have been synthesized and evaluated for biological activity. Oxygen substituted hydroxylamine compounds have been found to possess versatile pharmacological activities. Theophylline N-alkoxyarylbiguanides 8a-d have been prepared by condensing corresponding N-alkoxyamine salt 6a-c with substituted aryldicyandiamide 7, which in turn is prepared by Gabriel hydrolysis of corresponding alkoxyphthalimides 5a-c. Theophylline is converted to its sodium salt using sodium hydride and treated with bromoalkoxy phthalimide in DMF media. In an another attempt N-allyl theophylline 9 is brominated and condensed with double mole ratio of N-hydroxyphthalimide to obtain 2,3-bis-oxyphthalimido-1-theophylline propane 11. Majority of these compounds have been screened for their antimicrobial activity.|
|Appears in Collections:||IJC-B Vol.44B(10) [October 2005]|
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