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|Title:||Synthesis and antibacterial evaluation of some theophylline derivatives|
Talesara, G L
|Series/Report no.:||<b style="">Int</b>.<b style="">Cl</b>.<b style=""><sup>7</sup> C 07 D // A 61 P 31/04</b>|
|Abstract:||Some novel antiasthmatic theophylline derivatives have been synthesized and evaluated for biological activity. Oxygen substituted hydroxylamine compounds have been found to possess versatile pharmacological activities. Theophylline N-alkoxyarylbiguanides <b style="">8a-d</b> have been prepared by condensing corresponding N-alkoxyamine salt <b style="">6a-c</b> with substituted aryldicyandiamide <b style="">7</b>, which in turn is prepared by Gabriel hydrolysis of corresponding alkoxyphthalimides <b style="">5a-c</b>. Theophylline is converted to its sodium salt using sodium hydride and treated with bromoalkoxy phthalimide in DMF media. In an another attempt N-allyl theophylline <b style="">9</b> is brominated and condensed with double mole ratio of N-hydroxyphthalimide to obtain 2,3-bis-oxyphthalimido-1-theophylline propane <b style="">11</b>. Majority of these compounds have been screened for their antimicrobial activity.|
|Appears in Collections:||IJC-B Vol.44B(10) [October 2005]|
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