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Title: Synthesis and antibacterial evaluation of some theophylline derivatives
Authors: Rathore, Kavita
Vyas, Ritu
Talesara, G L
Keywords: Theophylline
antimicrobial activity
Issue Date: Oct-2005
Publisher: CSIR
Series/Report no.: <b style="">Int</b>.<b style="">Cl</b>.<b style=""><sup>7</sup> C 07 D // A 61 P 31/04</b>
Abstract: Some novel antiasthmatic theophylline derivatives have been synthesized and evaluated for biological activity. Oxygen substituted hydroxylamine compounds have been found to possess versatile pharmacological activities. Theophylline N-alkoxy­arylbiguanides <b style="">8a-d</b> have been prepared by condensing corres­ponding N-alkoxyamine salt <b style="">6a-c</b> with substituted aryldicyan­diamide <b style="">7</b>, which in turn is prepared by Gabriel hydrolysis of corresponding alkoxyphthalimides <b style="">5a-c</b>. Theophylline is converted to its sodium salt using sodium hydride and treated with bromoalkoxy phthalimide in DMF media. In an another attempt N-allyl theophylline <b style="">9</b> is brominated and condensed with double mole ratio of N-hydroxyphthalimide to obtain 2,3-bis-oxyphthalimido-1-theophylline propane <b style="">11</b>. Majority of these compounds have been screened for their antimicrobial activity.
Description: 2166-2170
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(10) [October 2005]

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