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Title: Synthesis and antibacterial evaluation of some theophylline derivatives
Authors: Rathore, Kavita
Vyas, Ritu
Talesara, G L
Keywords: Theophylline;N-alkoxyamine;antimicrobial activity;bromoalkoxyphthalimide;arylbiguanides
Issue Date: Oct-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D // A 61 P 31/04
Abstract: Some novel antiasthmatic theophylline derivatives have been synthesized and evaluated for biological activity. Oxygen substituted hydroxylamine compounds have been found to possess versatile pharmacological activities. Theophylline N-alkoxy­arylbiguanides 8a-d have been prepared by condensing corres­ponding N-alkoxyamine salt 6a-c with substituted aryldicyan­diamide 7, which in turn is prepared by Gabriel hydrolysis of corresponding alkoxyphthalimides 5a-c. Theophylline is converted to its sodium salt using sodium hydride and treated with bromoalkoxy phthalimide in DMF media. In an another attempt N-allyl theophylline 9 is brominated and condensed with double mole ratio of N-hydroxyphthalimide to obtain 2,3-bis-oxyphthalimido-1-theophylline propane 11. Majority of these compounds have been screened for their antimicrobial activity.
Page(s): 2166-2170
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(10) [October 2005]

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