NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(10) [October 2005] >

Title: Synthesis and antibacterial evaluation of some theophylline derivatives
Authors: Rathore, Kavita
Vyas, Ritu
Talesara, G L
Keywords: Theophylline
antimicrobial activity
Issue Date: Oct-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D // A 61 P 31/04
Abstract: Some novel antiasthmatic theophylline derivatives have been synthesized and evaluated for biological activity. Oxygen substituted hydroxylamine compounds have been found to possess versatile pharmacological activities. Theophylline N-alkoxy­arylbiguanides 8a-d have been prepared by condensing corres­ponding N-alkoxyamine salt 6a-c with substituted aryldicyan­diamide 7, which in turn is prepared by Gabriel hydrolysis of corresponding alkoxyphthalimides 5a-c. Theophylline is converted to its sodium salt using sodium hydride and treated with bromoalkoxy phthalimide in DMF media. In an another attempt N-allyl theophylline 9 is brominated and condensed with double mole ratio of N-hydroxyphthalimide to obtain 2,3-bis-oxyphthalimido-1-theophylline propane 11. Majority of these compounds have been screened for their antimicrobial activity.
Page(s): 2166-2170
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(10) [October 2005]

Files in This Item:

File Description SizeFormat
IJCB 44B(10) 2166-2170.pdf52.5 kBAdobe PDFView/Open
 Current Page Visits: 838 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 171577 since 01-Sep-2015  Last updated on 30-Jun-2016Webmaster: