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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(10) [October 2005] >
| Title: | Synthesis and antineoplastic activity of some 16- benzylidene substituted steroidal oximes |
| Authors: | Dubey, Sonal
Jindal, Dharam Paul
Piplani, Poonam |
| Keywords: | benzylidine substituted steroidal oximes
steroidal
antineoplastic activity
anticancer assay |
| Issue Date: | Oct-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 J // A 61 P |
| Abstract: |
Novel 16-benzylidine substituted steroidal oximes in
the androstene series have been designed, synthesized and evaluated for in
vitro antineoplastic activity at NCI, Bethesda,
USA against
3-cell lines using one dose primary anticancer assay. Of the compounds tested,
3β-hydroxy derivatives 24 (DPJ-1059),
26 (DPJ-1081), 28 (DPJ-870), 30 (DPJ-818), 32 (DPJ-854)
and 3β-acetoxy derivatives 25
(DPJ-1061), 27 (DPJ-1083), 31 (DPJ-817) and 33(DPJ-900) have been found to be quite active. |
| Page(s): | 2126-2137 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(10) [October 2005]
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