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Title: Synthesis and antineoplastic activity of some 16- benzylidene substituted steroidal oximes
Authors: Dubey, Sonal
Jindal, Dharam Paul
Piplani, Poonam
Keywords: benzylidine substituted steroidal oximes;steroidal;antineoplastic activity;anticancer assay
Issue Date: Oct-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 J // A 61 P
Abstract:  Novel 16-benzylidine substituted steroidal oximes in the androstene series have been designed, synthesized and evaluated for in vitro antineoplastic activity at NCI, Bethesda, USA against 3-cell lines using one dose primary anticancer assay. Of the compounds tested, 3β-hydroxy derivatives 24 (DPJ-1059), 26 (DPJ-1081), 28 (DPJ-870), 30 (DPJ-818), 32 (DPJ-854) and 3β-acetoxy derivatives 25 (DPJ-1061), 27 (DPJ-1083), 31 (DPJ-817) and 33(DPJ-900) have been found to be quite active.
Page(s): 2126-2137
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(10) [October 2005]

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