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|Title:||Synthesis of 5-(2-5'-aryl-3'-isoxazolyl)-3,6-dimethylisoxazolo[4,5-b]pyridines|
isoxa¬zole ring formation
|Series/Report no.:||Int.Cl.7 C 07 D|
|Abstract:||Isoxazolopyridine-N-oxides 2 are deoxygenated to pyridines 3 by treatment with PCl3. 5-Acetyl-3,6-dimethylisoxazolo[4,5-b]pyridine 3 is condensed with aromatic aldehydes to give , -unsaturated carbonyl moiety at position-5, which then cyclizes to isoxazole ring by reaction with hydroxylamine hydrochloride in sodium acetate-acetic acid to result in title compounds 7. All the new compounds 3-7 have been characterized by elemental analyses and spectral (IR, 1H NMR and mass) data.|
|Appears in Collections:||IJC-B Vol.44B(09) [September 2005]|
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